Osteoblast: BMP

Pathway ID: SIGNOR-OsteoBMP

Description: Bone Morphogenetic Proteins (BMPs) have an essential role in osteogenic differentiation. Moreover, BMPs are involved in Heterotopic Ossification (HO) that occurs in some muscle pathological conditions. These cytokines bind Type I and Type II serine/threonine receptors that transduce signal into the cell. SMAD-dependent pathway and SMAD-independent pathway (a MAPK signal transduction) up-regulate osteogenic transcription factors, such as RUNX2, DLX5 and SP7, starting osteoblast differentiation.

Curated by: Giulio Giuliani

14 Seed Entities

Organism:
Name Primary ID
BMPR2 Q13873
DLX5 P56178
BMP2 P12643
SMAD4 Q13485
RUNX2 Q13950
SMAD1/5/8/SMAD4 SIGNOR-C215
MAPK14 Q16539
MAP2K6 P52564
SMAD1/5/8 SIGNOR-PF35
SP7 Q8TDD2
Osteoblast_differentiation SIGNOR-PH9
BMPR1A P36894
MAP3K7 O43318
MAP2K3 P46734