| + |
ARID5B | up-regulates quantity by expression 
transcriptional regulation
|
GATA3 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256158 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29326336 |
We also observed that ARID5B regulates the expression of four major components of the TAL1 complex (namely, TAL1,GATA3, RUNX1, and MYB) in Jurkat cells. Knockdown of ARID5B resulted in reductions of the H3K27ac signals at those enhancer loci (Supplemental Fig. S6E–H) and down-regulation of all four factors at the mRNA (Fig. 6E) and protein levels (Fig. 6F). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID5B | up-regulates quantity by expression
transcriptional regulation
|
TAL1 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256157 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29326336 |
ARID5B positively regulates the expression of TAL1 and its regulatory partners. we also observed that ARID5B regulates the expression of four major components of the TAL1 complex (namely, TAL1,GATA3, RUNX1, and MYB) in Jurkat cells. Knockdown of ARID5B resulted in reductions of the H3K27ac signals at those enhancer loci (Supplemental Fig. S6E–H) and down-regulation of all four factors at the mRNA (Fig. 6E) and protein levels (Fig. 6F). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID5B | up-regulates activity 
binding
|
PHF2 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264515 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21532585 |
We found that phosphorylated PHF2 then associates with ARID5B, a DNA-binding protein, and induce demethylation of methylated ARID5B. Assembly of the PHF2–ARID5B complex, its recruitment to target promoters, and its H3H9Me2 demethylase activity were dependent on PKA activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID5B | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256156 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29326336 |
ARID5B transcriptionally activates the oncogene MYC in T-ALL cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID5B | up-regulates quantity by expression
transcriptional regulation
|
RUNX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256159 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29326336 |
We also observed that ARID5B regulates the expression of four major components of the TAL1 complex (namely, TAL1,GATA3, RUNX1, and MYB) in Jurkat cells. Knockdown of ARID5B resulted in reductions of the H3K27ac signals at those enhancer loci (Supplemental Fig. S6E–H) and down-regulation of all four factors at the mRNA (Fig. 6E) and protein levels (Fig. 6F). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID5B | up-regulates quantity by expression
transcriptional regulation
|
MYB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256160 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29326336 |
We also observed that ARID5B regulates the expression of four major components of the TAL1 complex (namely, TAL1,GATA3, RUNX1, and MYB) in Jurkat cells. Knockdown of ARID5B resulted in reductions of the H3K27ac signals at those enhancer loci (Supplemental Fig. S6E–H) and down-regulation of all four factors at the mRNA (Fig. 6E) and protein levels (Fig. 6F). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF2 | up-regulates activity
binding
|
ARID5B |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264514 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21532585 |
We found that phosphorylated PHF2 then associates with ARID5B, a DNA-binding protein, and induce demethylation of methylated ARID5B. Assembly of the PHF2–ARID5B complex, its recruitment to target promoters, and its H3H9Me2 demethylase activity were dependent on PKA activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ARID5B
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