Summary

Name NFIL3
Full Name Nuclear factor interleukin-3-regulated protein
Synonyms E4 promoter-binding protein 4, Interleukin-3 promoter transcriptional activator, Interleukin-3-binding protein 1, Transcriptional activator NF-IL3A | E4BP4, IL3BP1
Primary ID Q16649
Links - -
Type protein
Relations 12
Pathways Circadian clock
Function Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL3 0.548
Publications: 1 Organism: Hylobates Lar
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CYP3A4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PER1 0.357
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates img/indirect-activation.png Survival 0.7
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png Apoptosis 0.7
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png Cell_death 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png NFIL3 0.548
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SOSTDC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png NFIL3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding NFIL3 0.2
Publications: 1 Organism: In Vitro
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFIL3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NFIL3 0.303
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock