Relation Results

Identifier	Residue	Organism
SIGNOR-251539		Homo sapiens
pmid	sentence
15861399	AR homodimers recruit a panoply of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation

Publications:

1

Organism:

Homo Sapiens

Pathways:

Prostate Cancer

Identifier	Residue	Organism	Cell Line
SIGNOR-254953		Homo sapiens	Mast Cell
pmid	sentence
15526160	C-Kit promotes survival via PI3-kinase-dependent activation of Akt and phosphorylation of Bad, a pro-apoptotic molecule, at S136 in vivo.

Publications:

1

Organism:

Homo Sapiens

Pathways:

Inhibition of Apoptosis, Malignant Melanoma

Identifier	Residue	Organism	Cell Line
SIGNOR-255579		Homo sapiens	Monocyte
pmid	sentence
11602185	The GM-CSF promoted cell survival and proliferation correlated with MEK-1 dependent ERK1/2, Elk-1 and CREB phosphorylation and Egr-1, c-Fos expression as well as with increased STAT-5, AP-1, c-Myb and NF-kappaB DNA-binding.

Identifier	Residue	Organism	Cell Line
SIGNOR-254948		Homo sapiens	Mast Cell
pmid	sentence
15526160	Numerous studies have implicated the critical importance of the Ras/Erk pathway in cell division and survival

Publications:

2

Organism:

Homo Sapiens

Tissue:

Skeletal Muscle

Pathways:

Colorectal Carcinoma, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer

Identifier	Residue	Organism	Cell Line
SIGNOR-255578		Homo sapiens	Monocyte
pmid	sentence
19436055	The alternative survival and proliferation pathway triggered by higher concentrations of GM-CSF is dependent on the dodecamer assembly and involves the Jak/STAT, Ras/mitogen-activated protein kinase, and PI-3 kinase pathways

Publications:

1

Organism:

Homo Sapiens

Tissue:

Skeletal Muscle

Identifier	Residue	Organism	Cell Line
SIGNOR-242655		Chlorocebus aethiops	COS Cell
pmid	sentence
14665640	Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival

Publications:

1

Organism:

Chlorocebus Aethiops

Identifier	Residue	Organism
SIGNOR-229767		Homo sapiens
pmid	sentence
17081971	The interaction of beta-catenin with the N terminus of tcf/lef transiently converts it into an activator, translating the Wnt signal into the transient transcription of Tcf target genes. The Wnt pathway has distinct transcriptional outputs, which are determined by the identity of the responding cell, and range from cell proliferation and survival to the terminal differentiation of postmitotic cells.

Publications:

1

Organism:

Homo Sapiens

Pathways:

Colorectal Carcinoma, Hepatocellular Tumor, WNT Signaling

Identifier	Residue	Organism
SIGNOR-242468		Homo sapiens
pmid	sentence
26384349	Treatment with _-cyano-4-hydroxy cinnamate (CHC), a known inhibitor of MCT1, MCT2 and MCT4, dose-dependently induced cell death in MM cell lines and primary MM cells (Figure 1C). Thus, monocarboxylate transportation across membranes appears crucial for MM cell survival.

Publications:

1

Organism:

Homo Sapiens

Identifier	Residue	Organism
SIGNOR-242519		Homo sapiens
pmid	sentence
26384349	Treatment with _-cyano-4-hydroxy cinnamate (CHC), a known inhibitor of MCT1, MCT2 and MCT4, dose-dependently induced cell death in MM cell lines and primary MM cells (Figure 1C). Thus, monocarboxylate transportation across membranes appears crucial for MM cell survival.

Publications:

1

Organism:

Homo Sapiens

Identifier	Residue	Organism	Cell Line
SIGNOR-242652		Chlorocebus aethiops	COS Cell
pmid	sentence
14665640	Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival

Publications:

1

Organism:

Chlorocebus Aethiops

Identifier	Residue	Organism
SIGNOR-96834		Homo sapiens
pmid	sentence
14585074	Activation of the nf-kb pathway regulates a variety of ant-apoptotic factors

Publications:

1

Organism:

Homo Sapiens

Pathways:

Inhibition of Apoptosis, Pancreatic ductal adenocarcinoma (PDA)

Identifier	Residue	Organism	Cell Line
SIGNOR-242649		Chlorocebus aethiops	COS Cell
pmid	sentence
14665640	Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival

Publications:

1

Organism:

Chlorocebus Aethiops

Pathways:

Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer, Rhabdomyosarcoma

Identifier	Residue	Organism	Cell Line
SIGNOR-252706		Chlorocebus aethiops	COS Cell
pmid	sentence
14665640	Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival

Identifier	Residue	Organism	Cell Line
SIGNOR-255576		Homo sapiens	Monocyte
pmid	sentence
19436055	Low pM concentrations of GM-CSF mediate βc Ser585 phosphorylation, leading to 14-3-3 binding, PI-3 kinase activation, and hemopoietic cell survival, whereas at concentrations of 10 pM or more, GM-CSF mediates βc Tyr577 phosphorylation, Shc recruitment, and PI-3 kinase activation, thereby promoting both survival and proliferation.

Publications:

2

Organism:

Chlorocebus Aethiops, Homo Sapiens

Tissue:

Skeletal Muscle

Pathways:

ErbB receptors in cancer, Hepatocellular Tumor, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, RTKs in cancer

Identifier	Residue	Organism
SIGNOR-242537		Homo sapiens
pmid	sentence
15942022	Down-regulation of DNA topoisomerase IIalpha leads to prolonged cell cycle transit in G2 and early M phases and increased survival to microtubule-interacting agents

Publications:

1

Organism:

Homo Sapiens

Identifier	Residue	Organism	Cell Line
SIGNOR-254952		Homo sapiens	Mast Cell
pmid	sentence
15526160	c-Kit promotes survival via PI3-kinase-dependent activation of Akt and phosphorylation of Bad, a pro-apoptotic molecule, at S136 in vivo.

Identifier	Residue	Organism
SIGNOR-251550		Homo sapiens
pmid	sentence
16288293	Akt promotes both cell growth and cell survival by inactivating its downstream substrates including GSK3, BAD, FOXO and TSC2.

Publications:

2

Organism:

Homo Sapiens

Pathways:

ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Non-small-cell lung cancer (NSCLC), Prostate Cancer, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer

Identifier	Residue	Organism
SIGNOR-254779		Homo sapiens
pmid	sentence
27858941	DAB2IP inactivation promotes tumor growth and survival, development, and proliferation of CSC, and resistance to chemo- and radiotherapy. It induces EMT, increases cell migration and invasion, and counteracts pro-apoptotic signaling.

Publications:

1

Organism:

Homo Sapiens

Identifier	Residue	Organism
SIGNOR-229777		Homo sapiens
pmid	sentence
20660310	beta-catenin/CBP-driven transcription is critical for maintenance of an undifferentiated/proliferative state

Publications:

1

Organism:

Homo Sapiens

Pathways:

Glioblastoma Multiforme, Inhibition of Apoptosis, Malignant Melanoma, PI3K/AKT Signaling, WNT Signaling

Identifier	Residue	Organism
SIGNOR-242533		Homo sapiens
pmid	sentence
24463367	Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells

Publications:

1

Organism:

Homo Sapiens

Identifier	Residue	Organism	Cell Line
SIGNOR-242760		Mus musculus	Pro-B-lymphocyte
pmid	sentence
10082541	the effect of NFIL3 on cytokine-mediated cell survival was independent of an effect on cell proliferation.

Publications:

1

Organism:

Mus Musculus

Identifier	Residue	Organism	Cell Line
SIGNOR-242658		Chlorocebus aethiops	COS Cell
pmid	sentence
14665640	Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival

Publications:

1

Organism:

Chlorocebus Aethiops

Name	Survival
Primary ID	SIGNOR-PH13
Type	phenotype
Description	The process in which a cell actively inhibits apoptosis
Relations	22
Pathways	Colorectal Carcinoma, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Non-small-cell lung cancer (NSCLC), Prostate Cancer, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, WNT Signaling

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