| + |
NR0B2 | down-regulates quantity by repression 
transcriptional regulation
|
PCK2 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254832 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17094771 |
SHP repressed C/EBPalpha (CCAAT/enhancer-binding protein alpha)-driven transcription of PEPCK through direct interaction with C/EBPalpha protein both in vitro and in vivo. The formation of an active transcriptional complex of C/EBPalpha and its binding to DNA was inhibited by SHP, resulting in the inhibition of PEPCK gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | down-regulates quantity by repression
transcriptional regulation
|
PCK2 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255072 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20137375 |
NF-kappaB p65 was shown to inhibit transcription of phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme in gluconeogenesis in the liver |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
PCK2 | down-regulates quantity 
chemical modification
|
oxaloacetate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266556 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24632615 |
Phosphoenolpyruvate carboxykinase (PEPCK, EC 4.1.1.32) is a key enzyme of gluconeogenesis. Two isoforms exist, a cytoplasmic form (PCK1, PEPCK-C) and a mitochondrial isoform (PCK2, PEPCK-M). PEPCK activity is present at significant levels in the liver, but also in the kidney and in brown and white adipose tissue. PEPCK, which converts oxaloacetate (OAA) to PEP, has an important role in glucose formation, but also for the generation of glycerol and serine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
NCOA1 | up-regulates quantity by expression 
transcriptional regulation
|
PCK2 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255066 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
PCK2 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253773 |
|
|
Homo sapiens |
Hepatoma Cell |
| pmid |
sentence |
| 8093246 |
C/EBP beta can regulate PEPCK gene transcription by acting through the CRE and that C/EBP beta, together with CREB, may contribute to the cAMP responsiveness of the PEPCK promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCK2 | up-regulates quantity 
chemical modification
|
phosphonatoenolpyruvate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266557 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24632615 |
Phosphoenolpyruvate carboxykinase (PEPCK, EC 4.1.1.32) is a key enzyme of gluconeogenesis. Two isoforms exist, a cytoplasmic form (PCK1, PEPCK-C) and a mitochondrial isoform (PCK2, PEPCK-M). PEPCK activity is present at significant levels in the liver, but also in the kidney and in brown and white adipose tissue. PEPCK, which converts oxaloacetate (OAA) to PEP, has an important role in glucose formation, but also for the generation of glycerol and serine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
PCK2 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255060 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PCK2
- 
- 