Relation Results

Summary

Name FBXO31
Full Name F-box only protein 31
Synonyms FBX31_HUMAN | FBX14, FBX31
Primary ID Q5XUX0
Links - -
Type protein
Relations 8
Function Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes ...
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Type: Score: Layout: SPV 
0.4150.20.20.4220.5910.3290.3720.501ATMFBXO31AKT1CDH1CCND1Cullin 1-RBX1-Skp1MDM2CDC20Cullin 7-RBX1-Skp1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ATMup-regulates img/direct-activation.png phosphorylation FBXO31 0.415
Identifier Residue Sequence Organism Cell Line
SIGNOR-185635 Ser278 LMKFIYTsQYDNCLT Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell
pmid sentence
We find that dna damage induced by gamma-irradiation results in increased fbxo31 levels, which requires phosphorylation of fbxo31 by the ddr-initiating kinase atm
Publications: 1 Organism: Homo Sapiens
+ AKT1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FBXO31 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277376 Ser33 AETAAADsEPDTDPE Homo sapiens HEK-293T Cell
pmid sentence
Here we show that the low levels of FBXO31 are maintained through proteasomal degradation by anaphase-promoting complex/cyclosome (APC/C). We find that the APC/C coactivators CDH1 and CDC20 bind to a destruction-box (D-box) motif present in FBXO31 to promote its polyubiquitination and degradation in a cell-cycle-regulated manner, which requires phosphorylation of FBXO31 on serine-33 by the prosurvival kinase AKT.
Publications: 1 Organism: Homo Sapiens
+ CDH1down-regulates quantity by destabilization img/direct_inhibition.png binding FBXO31 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277377 Homo sapiens HEK-293T Cell
pmid sentence
Here we show that the low levels of FBXO31 are maintained through proteasomal degradation by anaphase-promoting complex/cyclosome (APC/C). We find that the APC/C coactivators CDH1 and CDC20 bind to a destruction-box (D-box) motif present in FBXO31 to promote its polyubiquitination and degradation in a cell-cycle-regulated manner, which requires phosphorylation of FBXO31 on serine-33 by the prosurvival kinase AKT.
Publications: 1 Organism: Homo Sapiens
+ FBXO31down-regulates quantity by destabilization img/direct_inhibition.png binding CCND1 0.422
Identifier Residue Sequence Organism Cell Line
SIGNOR-277379 Homo sapiens HEK-293T Cell
pmid sentence
FBXO31 serves as the substrate-recognition component of the SKP/Cullin/F-box protein class of E3 ubiquitin ligases and has been shown to direct degradation of pivotal cell-cycle regulatory proteins including cyclin D1 and the p53 antagonist MDM2.
Publications: 1 Organism: Homo Sapiens
+ FBXO31up-regulates activity img/direct-activation.png binding Cullin 1-RBX1-Skp1 0.591
Identifier Residue Sequence Organism Cell Line
SIGNOR-277382 Homo sapiens HEK-293T Cell
pmid sentence
FBXO31 serves as the substrate-recognition component of the SKP/Cullin/F-box protein class of E3 ubiquitin ligases and has been shown to direct degradation of pivotal cell-cycle regulatory proteins including cyclin D1 and the p53 antagonist MDM2.
Publications: 1 Organism: Homo Sapiens
+ FBXO31down-regulates quantity by destabilization img/direct_inhibition.png binding MDM2 0.329
Identifier Residue Sequence Organism Cell Line
SIGNOR-277380 Homo sapiens HEK-293T Cell
pmid sentence
FBXO31 serves as the substrate-recognition component of the SKP/Cullin/F-box protein class of E3 ubiquitin ligases and has been shown to direct degradation of pivotal cell-cycle regulatory proteins including cyclin D1 and the p53 antagonist MDM2.
Publications: 1 Organism: Homo Sapiens
+ CDC20down-regulates quantity by destabilization img/direct_inhibition.png binding FBXO31 0.372
Identifier Residue Sequence Organism Cell Line
SIGNOR-277378 Homo sapiens HEK-293T Cell
pmid sentence
Here we show that the low levels of FBXO31 are maintained through proteasomal degradation by anaphase-promoting complex/cyclosome (APC/C). We find that the APC/C coactivators CDH1 and CDC20 bind to a destruction-box (D-box) motif present in FBXO31 to promote its polyubiquitination and degradation in a cell-cycle-regulated manner, which requires phosphorylation of FBXO31 on serine-33 by the prosurvival kinase AKT.
Publications: 1 Organism: Homo Sapiens
+ FBXO31up-regulates activity img/direct-activation.png binding Cullin 7-RBX1-Skp1 0.501
Identifier Residue Sequence Organism Cell Line
SIGNOR-277381 Homo sapiens HEK-293T Cell
pmid sentence
FBXO31 serves as the substrate-recognition component of the SKP/Cullin/F-box protein class of E3 ubiquitin ligases and has been shown to direct degradation of pivotal cell-cycle regulatory proteins including cyclin D1 and the p53 antagonist MDM2.
Publications: 1 Organism: Homo Sapiens
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