4.0
Summary
| Name |  PHLPP2View Modifications |
| Full Name | PH domain leucine-rich repeat-containing protein phosphatase 2 |
| Synonyms | PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like | KIAA0931, PHLPPL |
| Primary ID | Q6ZVD8 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Function | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PHLPP2 | down-regulates activity 
dephosphorylation
|
AKT3 | 0.686 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PHLPP2 | down-regulates activity
dephosphorylation
|
AKT1 | 0.775 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHLPP2 | down-regulates
dephosphorylation
|
AKT1 | 0.775 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHLPP2 | down-regulates
dephosphorylation
|
AKT | 0.775 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHLPP2 | down-regulates activity
dephosphorylation
|
AKT2 | 0.607 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHLPP2 | down-regulates quantity
dephosphorylation
|
PRKCA | 0.254 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHLPP2 | down-regulates quantity
dephosphorylation
|
PRKCB | 0.327 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHLPP2 | down-regulates quantity by destabilization
dephosphorylation
|
PRKCB | 0.327 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHLPP2 | up-regulates activity 
dephosphorylation
|
STK4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHLPP2 | down-regulates activity
dephosphorylation
|
RPS6KB1 | 0.489 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHLPP2 | down-regulates activity
dephosphorylation
|
AKT | 0.775 |
| Publications: | 1 | Organism: | Homo Sapiens | |