Summary

Name TICAM2
Full Name TIR domain-containing adapter molecule 2
Synonyms TICAM-2, Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein, MyD88-4 | TIRAP3, TIRP, TRAM
Primary ID Q86XR7
Links - -
Type protein
Relations 6
Pathways Macrophage polarization, Toll like receptors
Function Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TICAM2 0.598
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TICAM1 0.564
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Toll like receptors
+ up-regulates activity img/direct-activation.png binding TICAM2 0.445
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding TICAM2 0.415
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding TICAM2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
+ up-regulates img/direct-activation.png binding TICAM2 0.722
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization