Summary

Name PRKCQ
Full Name Protein kinase C theta type
Synonyms nPKC-theta | PRKCT
Primary ID Q04759
Links - -
Type protein
Relations 21
Function Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation WIPF1 0.40
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ICAM3 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CARD11 0.68
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.28
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation RAPGEF2 0.55
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RASGRP3 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKCQ
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HABP4 0.38
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS3
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCQ
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MSN 0.40
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PRKCQ 0.40
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGB1 0.19
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png unknown PRKCQ 0.54
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding PKCtheta/Nfix
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation HSF1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKCQ
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCQ
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCQ 0.20
Publications: 1 Organism: Homo Sapiens