| + |
MAML2 | up-regulates quantity by expression 
transcriptional regulation
|
HES1 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94276 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12386158 |
Similarly, maml1 and maml2 amplified notch ligand (both jagged2 and delta1)-induced transcription of the hes-1 gene, whereas maml3 displayed little effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBPJ | up-regulates 
binding
|
MAML2 |
0.865 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176197 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21873209 |
When bound to the active intracellular domain of notch (nicd), rbpj recruits a coactivator complex, including a mastermind homologue (maml1-3 in mammals), and drives a complex transcriptional program with pervasive phenotypic effects |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH4 | up-regulates
binding
|
MAML2 |
0.854 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94279 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12386158 |
We show here identification of two new members of human mam family (human mastermind-2 (hmam-2) and human mastermind-3 (hmam-3)), which retain characteristics similar to human mastermind-1 (hmam-1) and drosophila mastermind. Both hmam-2 and hmam-3 stabilize and participate in the dna-binding complex rbp-j/cbf-1 protein and the notch intracellular domains that serve as intermediates of the signaling. Both hmam-2 and hmam-3 enhanced the activation of transcription from a target promoter by notch signaling. However, we also show evidence that the activation of the target promoter by notch3 and notch4 is more efficiently potentiated by hmam-2 than by hmam-1 or -3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML2 | up-regulates quantity by expression
transcriptional regulation
|
NOTCH |
0.857 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
We recently cloned a mammalian homologue of the mastermind gene of drosophila melanogaster, maml1 (mastermind-like-1 molecule) and determined that it functions as a transcriptional coactivator for notch receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML2 | up-regulates quantity by expression
transcriptional regulation
|
NOTCH1 |
0.832 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94065 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
We recently cloned a mammalian homologue of the mastermind gene of drosophila melanogaster, maml1 (mastermind-like-1 molecule) and determined that it functions as a transcriptional coactivator for notch receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates
binding
|
MAML2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254347 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12386158 |
Other than a role in t-cell development, the hox genes may be involved in alternative notchregulated processes in hematopoietic stem cells. Notch signaling is clearly important for self-renewal of hematopoietic progenitors (reviewed by radkte et al. 57). Interestingly, hoxa5, a9 and a10 were found to be part of the stem cell profile' |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAML2
- 
- 