3.0
Summary
| Name |  PMAIP1View Modifications |
| Full Name | Phorbol-12-myristate-13-acetate-induced protein 1 |
| Synonyms | PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa | NOXA |
| Primary ID | Q13794 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK5 | down-regulates 
phosphorylation
|
PMAIP1 | 0.365 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF7 | down-regulates activity
ubiquitination
|
PMAIP1 | 0.399 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TP53 | up-regulates quantity by expression 
transcriptional regulation
|
PMAIP1 | 0.691 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | TP73 | up-regulates quantity by expression
transcriptional regulation
|
PMAIP1 | 0.327 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FUBP1 | down-regulates quantity by repression 
transcriptional regulation
|
PMAIP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |