| + |
CDK1 | down-regulates activity 
phosphorylation
|
CDCA5 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276115 |
Ser126 |
NPEAESSsKEGELDA |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276125 |
Ser139 |
DARDLEMsKKVRRSY |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276120 |
Ser164 |
TSTPGRRsCFGFEGL |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276124 |
Ser33 |
LRRSQRKsGSELPSI |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276118 |
Ser83 |
PRRSPRIsFFLEKEN |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276121 |
Thr151 |
RSYSRLEtLGSASTS |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Publications: |
6 |
Organism: |
In Vitro |
| + |
AURKB | down-regulates activity
phosphorylation
|
CDCA5 |
0.614 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276123 |
Ser126 |
NPEAESSsKEGELDA |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276114 |
Ser139 |
DARDLEMsKKVRRSY |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276113 |
Ser164 |
TSTPGRRsCFGFEGL |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276116 |
Ser33 |
LRRSQRKsGSELPSI |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276119 |
Ser83 |
PRRSPRIsFFLEKEN |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276117 |
Thr151 |
RSYSRLEtLGSASTS |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Publications: |
6 |
Organism: |
In Vitro |
| + |
ERK1/2 | up-regulates activity 
phosphorylation
|
CDCA5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262968 |
Ser209 |
DMTLPGIsPPPEKQK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20551060 |
Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Our data suggest that transactivation of CDCA5 and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation, and that the selective suppression of the ERK-CDCA5 pathway could be a promising strategy for cancer therapy. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262969 |
Ser79 |
AVQSPRRsPRISFFL |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20551060 |
Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Our data suggest that transactivation of CDCA5 and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation, and that the selective suppression of the ERK-CDCA5 pathway could be a promising strategy for cancer therapy. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLK1 | down-regulates activity
phosphorylation
|
CDCA5 |
0.693 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276122 |
Thr151 |
RSYSRLEtLGSASTS |
in vitro |
|
| pmid |
sentence |
| 23901111 |
Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
YAP1 | up-regulates quantity by expression 
transcriptional regulation
|
CDCA5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276565 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
CDCA5 | down-regulates activity
binding
|
WAPL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265266 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 21111234 |
We show that DNA replication and cohesin acetylation promote binding of Sororin to cohesin, and that Sororin displaces Wapl from its binding partner Pds5. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
CDCA5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276577 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
3.0
CDCA5
- 
- 