| + |
TCF3 | down-regulates quantity by repression 
transcriptional regulation
|
BBC3 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255386 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23684607 |
The transcription factor TCF3, also known as E2A, drives p21 expression while repressing PUMA across cancer cell types of multiple origins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
E2F1 | up-regulates quantity by expression 
transcriptional regulation
|
BBC3 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253843 |
|
|
Homo sapiens |
SK-MEL-2 Cell |
| pmid |
sentence |
| 17263886 |
Up-regulation of the PUMA gene and protein by E2F-1 overexpression was detected by real-time PCR and Western blot analysis in the SK-MEL-2 melanoma cell line |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP73 | up-regulates quantity by expression
transcriptional regulation
|
BBC3 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255467 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
Dissociation of p73 and HDM2 leads to increased p73 transcriptional activity with upregulation of p73 target genes noxa, puma and p21, as well as enhanced apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM4B | down-regulates quantity by repression
transcriptional regulation
|
BBC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263733 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 28073943 |
JMJD2B induction attenuates the transcription of key p53 transcriptional targets including p21, PIG3 and PUMA, and this modulation is dependent on the catalytic capacity of JMJD2B. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETV6 | up-regulates quantity by expression
transcriptional regulation
|
BBC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254137 |
|
|
Mus musculus |
32D Clone3 Cell |
| pmid |
sentence |
| 16828711 |
Forced expression of TEL stimulated transcription via the p53-responsive element and increased the expression of cellular target genes for p53 such as cell cycle regulator p21 and apoptosis inducer Puma. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ERBB2 | down-regulates activity 
phosphorylation
|
BBC3 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24236056 |
These results show for the first time that PUMA can be phosphorylated at tyrosine residues directly by HER2.|Together, our results demonstrate, for the first time, that PUMA can be tyrosine phosphorylated and that HER2-mediated phosphorylation destabilizes PUMA protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BBC3
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- 