Relation Results

Summary

Name BBC3
Full Name Bcl-2-binding component 3, isoforms 3/4
Synonyms JFY-1, p53 up-regulated modulator of apoptosis | PUMA
Primary ID Q96PG8
Links - -
Type protein
Relations 6
Function [Isoform 3]

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Type: Score: Layout: SPV 
0.20.2830.2730.4250.4670.2ETV6BBC3ERBB2TCF3E2F1TP73KDM4B

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Relations
Regulator
Mechanism
target
score ℹ
+ ETV6up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BBC3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254137 Mus musculus 32D Clone3 Cell
pmid sentence
Forced expression of TEL stimulated transcription via the p53-responsive element and increased the expression of cellular target genes for p53 such as cell cycle regulator p21 and apoptosis inducer Puma.
Publications: 1 Organism: Mus Musculus
+ ERBB2down-regulates activity img/direct_inhibition.png phosphorylation BBC3 0.283
Identifier Residue Sequence Organism Cell Line
SIGNOR-278224 Homo sapiens
pmid sentence
These results show for the first time that PUMA can be phosphorylated at tyrosine residues directly by HER2.|Together, our results demonstrate, for the first time, that PUMA can be tyrosine phosphorylated and that HER2-mediated phosphorylation destabilizes PUMA protein.
Publications: 1 Organism: Homo Sapiens
+ TCF3down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BBC3 0.273
Identifier Residue Sequence Organism Cell Line
SIGNOR-255386 Homo sapiens
pmid sentence
The transcription factor TCF3, also known as E2A, drives p21 expression while repressing PUMA across cancer cell types of multiple origins.
Publications: 1 Organism: Homo Sapiens
+ E2F1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BBC3 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-253843 Homo sapiens SK-MEL-2 Cell
pmid sentence
Up-regulation of the PUMA gene and protein by E2F-1 overexpression was detected by real-time PCR and Western blot analysis in the SK-MEL-2 melanoma cell line
Publications: 1 Organism: Homo Sapiens
+ TP73up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BBC3 0.467
Identifier Residue Sequence Organism Cell Line
SIGNOR-255467 Homo sapiens
pmid sentence
Dissociation of p73 and HDM2 leads to increased p73 transcriptional activity with upregulation of p73 target genes noxa, puma and p21, as well as enhanced apoptosis.
Publications: 1 Organism: Homo Sapiens
+ KDM4Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BBC3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263733 Homo sapiens HCT-116 Cell
pmid sentence
JMJD2B induction attenuates the transcription of key p53 transcriptional targets including p21, PIG3 and PUMA, and this modulation is dependent on the catalytic capacity of JMJD2B.
Publications: 1 Organism: Homo Sapiens
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