| + |
MAPK3 | down-regulates 
phosphorylation
|
ETV6 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123656 |
Ser213 |
DNMIRRLsPAERAQG |
Mus musculus |
|
| pmid |
sentence |
| 15060146 |
Tel became phosphorylated by erk on two serine residues, ser213 and ser257, in the internal domain between the hlh and ets domains. Tel lost its abilities to repress transcription through the phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260085 |
Ser257 |
ESHPKPSsPRQESTR |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 15060146 |
Tel became phosphorylated by erk on two serine residues, ser213 and ser257, in the internal domain between the hlh and ets domains. Tel lost its abilities to repress transcription through the phosphorylation. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
MAPK1 | down-regulates
phosphorylation
|
ETV6 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260086 |
Ser213 |
DNMIRRLsPAERAQG |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 15060146 |
Tel became phosphorylated by erk on two serine residues, ser213 and ser257, in the internal domain between the hlh and ets domains. Tel lost its abilities to repress transcription through the phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260087 |
Ser257 |
ESHPKPSsPRQESTR |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 15060146 |
Tel became phosphorylated by erk on two serine residues, ser213 and ser257, in the internal domain between the hlh and ets domains. Tel lost its abilities to repress transcription through the phosphorylation. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
ERK1/2 | down-regulates
phosphorylation
|
ETV6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260084 |
Ser213 |
DNMIRRLsPAERAQG |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 15060146 |
Leukemia-related transcription factor TEL is negatively regulated through extracellular signal-regulated kinase-induced phosphorylation. Overexpressed TEL becomes phosphorylated in vivo by activated ERK. TEL is also directly phosphorylated in vitro by ERK. The inducible phosphorylation sites are Ser(213) and Ser(257). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, AML_TRIPLETS, Triple mutant AML |
| + |
ETV6 | up-regulates quantity by expression 
transcriptional regulation
|
HBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251793 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15958056 |
Upon erythropoietin exposure, overexpressed TEL stimulated hemoglobin synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETV6 | up-regulates
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256017 |
|
|
Homo sapiens |
UT-7 Cell, B-lymphoblastoid Cell Line |
| pmid |
sentence |
| 15958056 |
We thus conclude that TEL is also an accelerator for erythroid differentiation upon cytokine stimulation in human hematopoietic cells. We demonstrated in the present study that TEL accelerates erythroid differentiation induced by a physiological cytokine EPO in human leukemia cell line UT-7/GM. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, AML_TRIPLETS, Triple mutant AML |
| + |
ETV6 | up-regulates quantity by expression
transcriptional regulation
|
CDKN1A |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254138 |
|
|
Mus musculus |
32D Clone3 Cell |
| pmid |
sentence |
| 16828711 |
Forced expression of TEL stimulated transcription via the p53-responsive element and increased the expression of cellular target genes for p53 such as cell cycle regulator p21 and apoptosis inducer Puma. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia |
| + |
ETV6 | up-regulates quantity by expression
transcriptional regulation
|
BBC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254137 |
|
|
Mus musculus |
32D Clone3 Cell |
| pmid |
sentence |
| 16828711 |
Forced expression of TEL stimulated transcription via the p53-responsive element and increased the expression of cellular target genes for p53 such as cell cycle regulator p21 and apoptosis inducer Puma. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Gbeta | down-regulates
phosphorylation
|
ETV6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270120 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15060146 |
Tel became phosphorylated by erk on two serine residues, ser213 and ser257, in the internal domain between the hlh and ets domains. Tel lost its abilities to repress transcription through the phosphorylation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETV6 | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251794 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15958056 |
Upon erythropoietin exposure, overexpressed TEL stimulated hemoglobin synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM6A | down-regulates quantity by repression
transcriptional regulation
|
ETV6 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29736013 |
Our findings reveal a dual role for UTX in suppressing acute myeloid leukaemia via repression of oncogenic ETS and upregulation of tumor suppressive GATA programs. several ETS transcription factors, including Elf4, Etv6, Erg, Fli1, Ets2, Spi1 and Elk3 were upregulated immediately after Utx loss in the preleukaemic phase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCSK7 | down-regulates
phosphorylation
|
ETV6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95622 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12435397 |
In vivo p38-dependent phosphorylation reduced trans-repressional abilities of tel through ets-binding consensus site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ETV6
- 
- 