Summary

Name CDK5RAP2
Full Name CDK5 regulatory subunit-associated protein 2
Synonyms CDK5 activator-binding protein C48, Centrosome-associated protein 215 | CEP215, KIAA1633
Primary ID Q96SN8
Links - -
Type protein
Relations 13
Function Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation CDK5RAP2 0.524
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation APP 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization WDR62 0.569
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CDK5RAP2 0.813
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization CEP152 0.748
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TUBG1 0.634
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CDC20 0.319
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization CDK5RAP2 0.483
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BUB1B 0.276
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization CEP63 0.681
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MAD2L1 0.314
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization CDK5RAP2 0.468
Publications: 1
+ up-regulates activity img/direct-activation.png relocalization CDK5RAP2 0.649
Publications: 1 Organism: Homo Sapiens