Summary

Name PITX2
Full Name Pituitary homeobox 2
Synonyms ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin | ARP1, RGS, RIEG, RIEG1
Primary ID Q99697
Links - -
Type protein
Relations 5
Pathways WNT Signaling and Myogenesis
Function Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ PITX2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TBX1 0.437
Publications: 1 Organism: Homo Sapiens
+ PITX2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GNRH1 0.266
Publications: 1 Organism: Mus Musculus
+ PAX3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PITX2 0.282
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling and Myogenesis
+ LEF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PITX2 0.707
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ PITX2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.455
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:WNT Signaling and Myogenesis