Summary

Name IFIH1
Full Name Interferon-induced helicase C domain-containing protein 1
Synonyms Clinically amyopathic dermatomyositis autoantigen 140 kDa, CADM-140 autoantigen, Helicase with 2 CARD domains, Helicard, Interferon-induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5, MDA-5, Murabutide down-regulated protein, RIG-I-like receptor 2, RLR-2, RNA helicase-DEAD box protein 116 | MDA5, RH116
Primary ID Q9BYX4
Links - -
Type protein
Relations 9
Pathways COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA
Function Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ TRIM65up-regulates activity img/direct-activation.png ubiquitination IFIH1 0.45
Publications: 1 Organism: Homo Sapiens
+ RIOK3down-regulates activity img/direct_inhibition.png phosphorylation IFIH1 0.469
Publications: 1 Organism: Homo Sapiens
+ PPP1CCup-regulates activity img/direct-activation.png dephosphorylation IFIH1 0.247
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ PPP1CAup-regulates activity img/direct-activation.png dephosphorylation IFIH1 0.2
Publications: 1 Organism: Homo Sapiens
+ RNF125down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination IFIH1 0.657
Publications: 1 Organism: Homo Sapiens
+ Uridylate-specific endoribonucleasedown-regulates activity img/indirect_inhibition.png IFIH1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA
+ IFIH1up-regulates activity img/direct-activation.png binding MAVS 0.815
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA
+ Viral_dsRNAup-regulates img/direct-activation.png IFIH1 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA