| + |
POLR3A | up-regulates 
|
Viral_dsRNA |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265563 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19631370 |
Here we show that the cytosolic poly(dA-dT) DNA is converted into 5′-ppp RNA to induce IFN-β through the RIG-I pathway. Biochemical purification led to the identification of DNA-dependent RNA polymerase III (Pol-III) as the enzyme responsible for synthesizing 5′-ppp RNA from the poly(dA-dT) template. Inhibition of RNA Pol-III prevents IFN-β induction by transfection of DNA or infection with DNA viruses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Viral_dsRNA | up-regulates 
|
DDX1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260190 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21703541 |
We demonstrated here that DDX1-DDX21-DHX36 represents a dsRNA sensor that uses the adaptor molecule TRIF to activate the NF-κB pathway and type I IFN responses in dendritic cells. Our study suggests that the DDX1-DDX21-DHX36 complex represents this missing poly I:C sensor, which uses DDX1 to bind poly I:C and uses DDX21 and DXH36 to bind TRIF. Poly I:C is a synthetic form of RNA that mimics double-stranded viral RNA. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA |
| + |
Viral_dsRNA | up-regulates
|
EIF2AK2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260167 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226023 |
PKR is an interferon-stimulated gene (ISG) activated by binding of double-stranded RNA (dsRNA), a common intermediate during the replication of DNA and RNA viruses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS |
| + |
Viral_dsRNA | up-regulates
|
DDX58 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260141 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19052324 |
Initially, RIG-I and MDA5 sense dsRNA in the cytoplasm, produced as a by-product of RNA virus replication.Once one or both of these sensors are activated, they interact with a mitochondrial membrane protein called MAVS (mitochondrial antiviral) (also called IPS1, Cardif, and VISA). They signal to the mitochondrial membrane protein MAVS, which in turn activates the kinases TBK1 and IKKɛ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES |
| + |
Viral_replication | up-regulates
|
Viral_dsRNA |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260587 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226023 |
Double-stranded RNA (dsRNA), a common intermediate during the replication of DNA and RNA viruses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA |
| + |
Viral_dsRNA | up-regulates activity
binding
|
G3BP1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260979 |
|
|
|
|
| pmid |
sentence |
| 30804210 |
The RGG domain of G3BP1 could mediate the direct binding of HCV-dsRNA and poly(IC) |
|
| Publications: |
1 |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES |
| + |
Viral_dsRNA | up-regulates
|
IFIH1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260142 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19052324 |
Initially, RIG-I and MDA5 sense dsRNA in the cytoplasm, produced as a by-product of RNA virus replication.Once one or both of these sensors are activated, they interact with a mitochondrial membrane protein called MAVS (mitochondrial antiviral) (also called IPS1, Cardif, and VISA). They signal to the mitochondrial membrane protein MAVS, which in turn activates the kinases TBK1 and IKKɛ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA |
3.0
Viral_dsRNA