| + |
CyclinD1/CDK6 | up-regulates activity 
phosphorylation
|
TSC2 |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274101 |
Ser1217 |
MSLENPLsPFSSDIN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32294430 |
We show here that CyclinD-Cdk4/6 activates mTORC1 by binding and phosphorylating TSC2 on Ser1217 and Ser1452. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274102 |
Ser1452 |
LPSSSPRsPSGLRPR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32294430 |
We show here that CyclinD-Cdk4/6 activates mTORC1 by binding and phosphorylating TSC2 on Ser1217 and Ser1452. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CyclinD1/CDK6 | down-regulates activity 
phosphorylation
|
CTNNB1 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250647 |
Ser45 |
GATTTAPsLSGKGNP |
in vitro |
|
| pmid |
sentence |
| 17208333 |
We showed that CCND1-CDK6 phosphorylates beta-catenin on serine 45 (S45). This phosphorylation creates a priming site for glycogen synthase kinase 3beta (GSK3beta) and is both necessary and sufficient to initiate the beta-catenin phosphorylation-degradation cascade. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Pancreatic ductal adenocarcinoma (PDA) |
| + |
CyclinD1/CDK6 | up-regulates activity
phosphorylation
|
NDEL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250652 |
Thr245 |
GFGTSPLtPSARISA |
Mus musculus |
Brain |
| pmid |
sentence |
| 12796778 |
Three specific phosphorylation sites (Ser198, Thr219 and Ser231) and two weak phosphorylation sites (Ser242 and Thr245) for CDK5/p35 are located in this region of NUDEL | Each single or double mutant compromised,and the triple mutant completely eliminated, interaction with 14-3-3ε. | 14-3-3ε sustains NUDEL phosphorylation and protects it from phosphatase.e dynein motor function. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CCND1 | form complex 
binding
|
CyclinD1/CDK6 |
0.95 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8114739 |
Here, we show that the human PLSTIRE gene product is a novel cyclin-dependent kinase, cdk6. The cdk6 kinase is associated with cyclins D1, D2, and D3 in lysates of human cells and is activated by coexpression with D-type cyclins in Sf9 insect cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN2A | down-regulates
binding
|
CyclinD1/CDK6 |
0.803 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259810 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8891723 |
The first group, including p16ink4a, p15ink4b,p18ink4cand p19ink4d, is specific for the g1 cdks,cdk4and cdk6, inhibiting the kinase activity of cyclin d/cdk4-cdk6 complexes on prb. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pancreatic ductal adenocarcinoma (PDA) |
| + |
CDK6 | form complex
binding
|
CyclinD1/CDK6 |
0.95 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250681 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8114739 |
Here, we show that the human PLSTIRE gene product is a novel cyclin-dependent kinase, cdk6. The cdk6 kinase is associated with cyclins D1, D2, and D3 in lysates of human cells and is activated by coexpression with D-type cyclins in Sf9 insect cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinD1/CDK6 | up-regulates 
|
G0/G1_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273192 |
|
|
|
|
| pmid |
sentence |
| 12640120 |
Transition through this point requires cdk6/4-cyclin D, since inhibition with TAT-p16INK4A during the first 3 to 5 h prevents cell cycle entry and maintains both naive and memory T cells in G0. |
|
| Publications: |
1 |
3.0
CyclinD1/CDK6
CPX-2014