| + |
NBR1 | up-regulates 
binding
|
MAP1LC3A |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184270 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19250911 |
We performed glutathione s-transferase (gst) pull-down assays using extracts from hek293 cells overexpressing an ha-tagged nbr1(d50r) mutant, which lacks the ability to bind p62 (lamark et al., 2003) and gst fusions of six human atg8 homologs: gabarap, gabarapl1, gabarapl2, lc3a, lc3b, and lc3c. Indeed, nbr1 interacted with all these members of the mammalian atg8 protein family. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATG7 | up-regulates
binding
|
MAP1LC3A |
0.867 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195236 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22170151 |
Lc3-i is activated by the same atg7 involved in atg12 conjugation, transferred to atg3, a second e2-like enzyme, and finally conjugated to pe |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53INP2 | up-regulates
binding
|
MAP1LC3A |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182614 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19056683 |
Tp53inp2 is a scaffold protein that recruits lc3 and/or lc3-related proteins to the autophagosome membrane by interacting with the transmembrane protein vmp1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53INP1 | up-regulates
binding
|
MAP1LC3A |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22421968 |
Tp53inp1-lc3 interaction occurs via a functional lc3-interacting region (lir). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP1LC3A | up-regulates
binding
|
O-phosphoethanolamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191546 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22170151 |
Lc3-i is activated by the same atg7 involved in atg12 conjugation, transferred to atg3, a second e2-like enzyme, and finally conjugated to pe |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP1LC3A | up-regulates
binding
|
SQSTM1 |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184198 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19250911 |
Sqstm1/p62 (named a170 in the mouse;hereafter p62) is the first proposed example of such proteins (bj_?_?Rk_?_?Y et al.,2005). It binds polyubiquitinated protein aggregates via its uba domain and interacts with lc3 on the autophagosome/ this interaction is necessary for autophagic degradation of p62-positive cytoplasmic inclusion bodies containing ubiquitinated proteins. We also demonstrate that alis are indistinguishable from p62 inclusion bodies and that p62 is required for their formation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156353 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17580304 |
Sqstm1/p62 (named a170 in the mouse;hereafter p62) is the first proposed example of such proteins (bj_?_?Rk_?_?Y et al.,2005). It binds polyubiquitinated protein aggregates via its uba domain and interacts with lc3 on the autophagosome/ this interaction is necessary for autophagic degradation of p62-positive cytoplasmic inclusion bodies containing ubiquitinated proteins. We also demonstrate that alis are indistinguishable from p62 inclusion bodies and that p62 is required for their formation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FYCO1 | up-regulates activity
binding
|
MAP1LC3A |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260598 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26468287 |
The preferential binding to LC3A and -B was confirmed in vivo by co-immunoprecipitation experiments of Myc-tagged FYCO1 and GFP fusions of human ATG8 family pro-teins expressed in HEK293 cells (Fig. 2B). GFP-LC3A and GFP-LC3B were efficiently co-precipitated with Myc-FYCO1,whereas GFP-LC3C, GFP-GABARAP, GFP-GABARAPL1 and-L2 were not. The effects we see on late steps of basal autophagy on mutation of the FYCO1 LIR motif correlate with a role of FYCO1 in regulating kinesin-mediated transport of LC3-positive autophagic structures. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP1LC3A | up-regulates
binding
|
ATG3 |
0.85 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191543 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22170151 |
Lc3-i is activated by the same atg7 involved in atg12 conjugation, transferred to atg3, a second e2-like enzyme, and finally conjugated to pe. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP1LC3A | up-regulates 
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219406 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20921139 |
We assessed both conversion of LC3-I to its cleaved and lipidated form LC3-II and its translocation to autophagic structures, two steps in autophagosome formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Fibroma Cell |
3.0
MAP1LC3A
- 
- 