Summary

Name CYLD
Full Name Ubiquitin carboxyl-terminal hydrolase CYLD
Synonyms Deubiquitinating enzyme CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD | CYLD1, KIAA0849
Primary ID Q9NQC7
Links - -
Type protein
Relations 29
Pathways NF-KB Canonical
Function Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18636086, PubMed:26670046, PubMed:27458237, PubMed:26997266, PubMed:27591049, PubMed:29291351, PubMed:18313383). Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CAMK2Bup-regulates img/direct-activation.png phosphorylation CYLD 0.2
Publications: 2 Organism: Homo Sapiens
+ CAMK2Aup-regulates activity img/direct-activation.png phosphorylation CYLD 0.311
Publications: 4 Organism: Homo Sapiens
+ IKK-complexdown-regulates activity img/direct_inhibition.png phosphorylation CYLD 0.615
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ CAMK2Bup-regulates activity img/direct-activation.png phosphorylation CYLD 0.2
Publications: 1 Organism: Homo Sapiens
+ IKBKBdown-regulates activity img/direct_inhibition.png phosphorylation CYLD 0.529
Publications: 6 Organism: Homo Sapiens
+ CHUKdown-regulates activity img/direct_inhibition.png phosphorylation CYLD 0.524
Publications: 5 Organism: Homo Sapiens
+ CHUKup-regulates activity img/direct-activation.png phosphorylation CYLD 0.524
Publications: 2 Organism: Homo Sapiens
+ IKBKBup-regulates activity img/direct-activation.png phosphorylation CYLD 0.529
Publications: 2 Organism: Homo Sapiens
+ CYLDup-regulates img/indirect-activation.png CCND1 0.401
Publications: 1 Organism: Homo Sapiens
+ CYLDdown-regulates activity img/direct_inhibition.png deubiquitination TRAF2 0.664
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ TRIM47down-regulates quantity img/direct_inhibition.png ubiquitination CYLD 0.2
Publications: 1 Organism: Mus Musculus
+ CYLDdown-regulates img/direct_inhibition.png deubiquitination TRAF6 0.781
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
Pathways:NF-KB Canonical
+ CYLDdown-regulates img/direct_inhibition.png deubiquitination BCL3 0.527
Publications: 1 Organism: Homo Sapiens
+ CYLDup-regulates activity img/direct-activation.png deubiquitination MAP3K7 0.62
Publications: 1 Organism: Mus Musculus
Pathways:NF-KB Canonical