Summary

Name RNF146
Full Name E3 ubiquitin-protein ligase RNF146
Synonyms Dactylidin, Iduna, RING finger protein 146, RING-type E3 ubiquitin transferase RNF146 |
Primary ID Q9NTX7
Links - -
Type protein
Relations 13
Pathways Wnt in cancer
Function E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AXIN2 0.656
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RNF146 0.599
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination GSK3B/Axin/APC 0.516
Publications: 1 Organism: Homo Sapiens
Pathways:Wnt in cancer
+ down-regulates quantity img/direct_inhibition.png ubiquitination TNKS 0.714
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RNF146 0.714
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AXIN1 0.634
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination RNF146 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination RNF146 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Wnt in cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CASC3 0.267
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination AXIN2 0.656
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination AXIN1 0.634
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination BLZF1 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination TNKS2 0.599
Publications: 1 Organism: Homo Sapiens