Summary

Name ASH2L
Full Name Set1/Ash2 histone methyltransferase complex subunit ASH2
Synonyms ASH2-like protein | ASH2L1
Primary ID Q9UBL3
Links - -
Type protein
Relations 5
Function Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).

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Relations

Regulator Mechanism target score ℹ
+ MEF2Dup-regulates img/indirect-activation.png ASH2L 0.478
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ ASH2Lup-regulates activity img/direct-activation.png binding TBX1 0.313
Publications: 1 Organism: Homo Sapiens
+ ASH2Lup-regulates img/direct-activation.png binding GATA3 0.252
Publications: 1 Organism: Homo Sapiens
+ ASH2Lform complex img/form-complex.png binding HMT 0.869
Publications: 1 Organism: Homo Sapiens
+ ASH2Lform complex img/form-complex.png binding Set1-Ash2 HMT complex 0.909
Publications: 1 Organism: Homo Sapiens