Relation Results

Summary

Name ASH2L
Full Name Set1/Ash2 histone methyltransferase complex subunit ASH2
Synonyms ASH2-like protein | ASH2L1
Primary ID Q9UBL3
Links - -
Type protein
Relations 5
Function Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcripti ...
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Type: Score: Layout: SPV 
0.250.8740.3090.9120.468ASH2LGATA3HMTTBX1Set1-Ash2 HMT complexMEF2D

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Relations
Regulator
Mechanism
target
score ℹ
+ ASH2Lup-regulates img/direct-activation.png binding GATA3 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-205312 Homo sapiens Breast Cancer Cell
pmid sentence
We identifiedgata3as the binding protein of ash2l. Ash2l was shown to potentiate the transcriptional activity ofgata3.
Publications: 1 Organism: Homo Sapiens
+ ASH2Lform complex img/form-complex.png binding HMT 0.874
Identifier Residue Sequence Organism Cell Line
SIGNOR-154760 Homo sapiens
pmid sentence
The evolutionarily conserved hdpy-30, ash2l, rbbp5, and wdr5 likely constitute a subcomplex that is shared by all human set1-like hmt complexes.
Publications: 1 Organism: Homo Sapiens
+ ASH2Lup-regulates activity img/direct-activation.png binding TBX1 0.309
Identifier Residue Sequence Organism Cell Line
SIGNOR-251868 Homo sapiens
pmid sentence
Tbx1 interacts with Ash2l in both yeast and mammalian cells and Ash2l acts as a transcriptional co-activator in luciferase reporter assays.
Publications: 1 Organism: Homo Sapiens
+ ASH2Lform complex img/form-complex.png binding Set1-Ash2 HMT complex 0.912
Identifier Residue Sequence Organism Cell Line
SIGNOR-264479 Homo sapiens HeLa Cell
pmid sentence
Our analysis of HCF-1-associated proteins suggests that a K4 histone H3 HMT complex has been conserved from yeast to humans in both structure and activity: the Set1/Ash2 HMT. The results presented here show that this Set1/Ash2 HMT complex, in mutually exclusive interactions, can associate with HCF-1 bound to the repressive Sin3 HDAC or the transcriptional activator VP16, indicating a diversity of transcriptional regulatory roles.
Publications: 1 Organism: Homo Sapiens
+ MEF2Dup-regulates img/indirect-activation.png ASH2L 0.468
Identifier Residue Sequence Organism Cell Line
SIGNOR-159334 Homo sapiens
pmid sentence
Targeting of ash2l to specific genes is mediated by the transcriptional regulator mef2d. Furthermore, this interaction is modulated during differentiation through activation of the p38 mapk signaling pathway via phosphorylation of mef2d.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
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