| + |
CSNK2A2 | up-regulates activity 
phosphorylation
|
PPP1R1B |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251018 |
Ser102 |
NLNENQAsEEEDELG |
in vitro |
|
| pmid |
sentence |
| 2557337 |
Study of [Plphosphate release during manual Edman degradation confirmed that the phosphorylated residues in rat DARPP-32 were Ser45 and Ser102. | Phosphorylation by casein kinase II did not affect the potency of DARPP-32 as an inhibitor of protein phosphatase-1, which depended only on phosphorylation of Thr34 by cAMP-dependent protein kinase. However, phosphorylation of DARPP-32 by casein kinase II facilitated phosphorylation of Thr34 by cAMP-dependent protein kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251019 |
Ser45 |
LFRLSEHsSPEEEAS |
in vitro |
|
| pmid |
sentence |
| 2557337 |
Study of [Plphosphate release during manual Edman degradation confirmed that the phosphorylated residues in rat DARPP-32 were Ser45 and Ser102. | Phosphorylation by casein kinase II did not affect the potency of DARPP-32 as an inhibitor of protein phosphatase-1, which depended only on phosphorylation of Thr34 by cAMP-dependent protein kinase. However, phosphorylation of DARPP-32 by casein kinase II facilitated phosphorylation of Thr34 by cAMP-dependent protein kinase |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
PPP1R1B |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250927 |
Ser102 |
NLNENQAsEEEDELG |
in vitro |
|
| pmid |
sentence |
| 2557337 |
Study of [Plphosphate release during manual Edman degradation confirmed that the phosphorylated residues in rat DARPP-32 were Ser45 and Ser102. | Phosphorylation by casein kinase II did not affect the potency of DARPP-32 as an inhibitor of protein phosphatase-1, which depended only on phosphorylation of Thr34 by cAMP-dependent protein kinase. However, phosphorylation of DARPP-32 by casein kinase II facilitated phosphorylation of Thr34 by cAMP-dependent protein kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250928 |
Ser45 |
LFRLSEHsSPEEEAS |
in vitro |
|
| pmid |
sentence |
| 2557337 |
Study of [Plphosphate release during manual Edman degradation confirmed that the phosphorylated residues in rat DARPP-32 were Ser45 and Ser102. | Phosphorylation by casein kinase II did not affect the potency of DARPP-32 as an inhibitor of protein phosphatase-1, which depended only on phosphorylation of Thr34 by cAMP-dependent protein kinase. However, phosphorylation of DARPP-32 by casein kinase II facilitated phosphorylation of Thr34 by cAMP-dependent protein kinase |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
PRKACA | up-regulates activity
phosphorylation
|
PPP1R1B |
0.504 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250031 |
Thr34 |
MIRRRRPtPAMLFRL |
|
|
| pmid |
sentence |
| 10604473 |
DARPP-32 (dopamine and cyclic AMP-regulated phospho-protein, relative molecular mass 32,000) is converted into an inhibitor of protein phosphatase 1 when it is phosphorylated by protein kinase A (PKA) at threonine 34.‚ |
|
| Publications: |
1 |
| + |
PKA | up-regulates activity
phosphorylation
|
PPP1R1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264956 |
Thr34 |
MIRRRRPtPAMLFRL |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10604473 |
DARPP-32 (dopamine and cyclic AMP-regulated phospho-protein, relative molecular mass 32,000) is converted into an inhibitor of protein phosphatase 1 when it is phosphorylated by protein kinase A (PKA) at threonine 34.‚ |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
| + |
CDK5 | up-regulates activity
phosphorylation
|
PPP1R1B |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250671 |
Thr75 |
RPNPCAYtPPSLKAV |
Rattus norvegicus |
Brain |
| pmid |
sentence |
| 10604473 |
We find that DARPP-32 is converted into an inhibitor of PKA when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (Cdk5). Cdk5 phosphorylates DARPP-32 in vitro and in intact brain cells. Phospho-Thr 75 DARPP-32 inhibits PKA in vitro by a competitive mechanism. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Dopaminergic Synapse |
| + |
PPP1R1B | down-regulates activity 
binding
|
PPP1CC |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264958 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10604473 |
DARPP-32 (dopamine and cyclic AMP-regulated phospho-protein, relative molecular mass 32,000) is converted into an inhibitor of protein phosphatase 1 when it is phosphorylated by protein kinase A (PKA) at threonine 34.‚ |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KB1 | up-regulates activity
phosphorylation
|
PPP1R1B |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33353667 |
D1R-PKA appears intact and elevated DARPP-32(pT34) in Rheb(S16H) mice is reduced by S6K1 inhibition (Figure 3).|S6K1 directly phosphorylates DARPP-32. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1E | up-regulates activity
phosphorylation
|
PPP1R1B |
0.322 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279701 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18991847 |
CKIepsilon phosphorylates and activates DARPP-32, a key molecule in various complex signaling pathways, including dopamine and glutamine signaling, which have both been demonstrated to be main pathways in substance dependence. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1R1B | down-regulates activity
binding
|
PPP1CB |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264959 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10604473 |
DARPP-32 (dopamine and cyclic AMP-regulated phospho-protein, relative molecular mass 32,000) is converted into an inhibitor of protein phosphatase 1 when it is phosphorylated by protein kinase A (PKA) at threonine 34.‚ |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1R1B | down-regulates activity
binding
|
PP1 |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269869 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10604473 |
DARPP-32 (dopamine and cyclic AMP-regulated phospho-protein, relative molecular mass 32,000) is converted into an inhibitor of protein phosphatase 1 when it is phosphorylated by protein kinase A (PKA) at threonine 34.‚  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1R1B | down-regulates activity
binding
|
PKA |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265087 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10604473 |
We find that DARPP-32 is converted into an inhibitor of PKA when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (Cdk5). Cdk5 phosphorylates DARPP-32 in vitro and in intact brain cells. Phospho-Thr 75 DARPP-32 inhibits PKA in vitro by a competitive mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
| + |
PPP1R1B | down-regulates activity
binding
|
PPP1CA |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264957 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10604473 |
DARPP-32 (dopamine and cyclic AMP-regulated phospho-protein, relative molecular mass 32,000) is converted into an inhibitor of protein phosphatase 1 when it is phosphorylated by protein kinase A (PKA) at threonine 34.‚ |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
3.0
PPP1R1B
- 
- 