Summary

Name RAB21
Full Name Ras-related protein Rab-21
Synonyms RAB21_HUMAN | KIAA0118
Primary ID Q9UL25
Links - -
Type protein
Relations 3
Pathways Macropinocytosis
Function Small GTPase involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601).

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Relations

Regulator Mechanism target score ℹ
+ RAB21form complex img/form-complex.png binding Early Endosome 0.4
Publications: 1 Organism: Homo Sapiens
+ 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphatedown-regulates activity img/direct_inhibition.png binding RAB21 0.8
Publications: 1 Organism: Homo Sapiens
+ RAB21up-regulates img/indirect-activation.png binding Early macropinosomes 0.7
Publications: 1 Organism: Homo Sapiens