Summary

Name CBLC
Full Name E3 ubiquitin-protein ligase CBL-C
Synonyms RING finger protein 57, SH3-binding protein CBL-3, SH3-binding protein CBL-C, Signal transduction protein CBL-C | CBL3, RNF57
Primary ID Q9ULV8
Links - -
Type protein
Relations 9
Function Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CBLC 0.551
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CBLC 0.46
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination LRIG1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png binding CBLC 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBLC 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates activity img/direct-activation.png ubiquitination CBLC 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CBLC 0.276
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CBLC 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.762
Publications: 1 Organism: Chlorocebus Aethiops