Summary

Name EIF2AK2
Full Name Interferon-induced, double-stranded RNA-activated protein kinase
Synonyms Eukaryotic translation initiation factor 2-alpha kinase 2, eIF-2A protein kinase 2, Interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein kinase, Protein kinase RNA-activated, PKR, Protein kinase R, Tyrosine-protein kinase EIF2AK2, 2.7.10.2, p68 kinase | PKR, PRKR
Primary ID P19525
Links - -
Type protein
Relations 35
Pathways COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
Function IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19507191, PubMed:19189853, PubMed:21123651, PubMed:21072047, PubMed:22948139, PubMed:23229543, PubMed:22381929). Inhibits viral replication via the integrated stress response (ISR)

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation EIF2AK2 0.2
Publications: 7 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
+ up-regulates img/direct-activation.png phosphorylation PPP2R5A 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.511
Publications: 1
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ up-regulates img/direct-activation.png phosphorylation TP53 0.548
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EIF2S1 0.715
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
+ up-regulates activity img/direct-activation.png phosphorylation EIF2AK2 0.2
Publications: 8 Organism: Saccharomyces Cerevisiae, Homo Sapiens, In Vitro
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
+ up-regulates img/direct-activation.png phosphorylation EIF2AK2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EIF2AK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK1 0.333
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NLRC4 inflammasome 0.315
Publications: 1 Organism: Homo Sapiens
Pathways:Inflammosome Activation
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EIF2AK2 0.493
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inflammosome Activation, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates img/indirect-activation.png Immune_response 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV STRESS GRANULES
+ up-regulates activity img/direct-activation.png binding NLRP3 inflammasome 0.332
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates activity img/direct-activation.png binding EIF2AK2 0.469
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EIF2AK2 0.315
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES
+ down-regulates activity img/indirect_inhibition.png EIF2AK2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV CYTOKINE STORM, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
+ up-regulates activity img/direct-activation.png binding AIM2 inflammasome 0.321
Publications: 1 Organism: Homo Sapiens
Pathways:Inflammosome Activation
+ up-regulates activity img/direct-activation.png binding NLRP1 inflammasome 0.308
Publications: 1 Organism: Homo Sapiens
Pathways:Inflammosome Activation
+ up-regulates img/indirect-activation.png EIF2AK2 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF2S1 0.715
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
+ down-regulates activity img/direct_inhibition.png binding EIF2AK2 0.617
Publications: 1 Organism: Homo Sapiens