| + |
FUS | up-regulates activity 
sumoylation
|
PA2G4 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249657 |
Lys298 |
MGVVECAkHELLQPF |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19946338 |
Here, we show that Ebp1 p42 isoform can be sumoylated on both K93 and K298 residues, which mediate its nuclear translocation and are required for its anti-proliferative activity .. Hence, TLS-mediated sumoylation is required for Ebp1 transcriptional repressive activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236904 |
Lys93 |
VCHFSPLkSDQDYIL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19946338 |
Here, we show that Ebp1 p42 isoform can be sumoylated on both K93 and K298 residues, which mediate its nuclear translocation and are required for its anti-proliferative activity .. Hence, TLS-mediated sumoylation is required for Ebp1 transcriptional repressive activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKCD | up-regulates
phosphorylation
|
PA2G4 |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170348 |
Ser360 |
ELKALLQsSASRKTQ |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21145366 |
Trk receptor activation by both ngf and bdnf induced phosphorylation of ebp1 at the s360 upon the activation of protein kinase c (pkc ) and triggered dissociation of p48 from retinoblastoma (rb |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCG |
phosphorylation
|
PA2G4 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249091 |
Ser363 |
ALLQSSAsRKTQKKK |
Homo sapiens |
|
| pmid |
sentence |
| 11325528 |
We found that Ebp1 was basally phosphorylated in AU565 breast cancer cells on serine/threonine residues and that this phosphorylation was enhanced by heregulin treatment. Both serine and threonine residues of a GST-Ebp1 fusion protein were phosphorylated by PKC in vitro. In vivo, we demonstrated that basal Ebp1 phosphorylation was dependent upon PKC. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249094 |
Thr366 |
QSSASRKtQKKKKKK |
Homo sapiens |
AU-565 Cell |
| pmid |
sentence |
| 11325528 |
We found that Ebp1 was basally phosphorylated in AU565 breast cancer cells on serine/threonine residues and that this phosphorylation was enhanced by heregulin treatment. Both serine and threonine residues of a GST-Ebp1 fusion protein were phosphorylated by PKC in vitro. In vivo, we demonstrated that basal Ebp1 phosphorylation was dependent upon PKC. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKCB |
phosphorylation
|
PA2G4 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249090 |
Ser363 |
ALLQSSAsRKTQKKK |
Homo sapiens |
AU-565 Cell |
| pmid |
sentence |
| 11325528 |
We found that Ebp1 was basally phosphorylated in AU565 breast cancer cells on serine/threonine residues and that this phosphorylation was enhanced by heregulin treatment. Both serine and threonine residues of a GST-Ebp1 fusion protein were phosphorylated by PKC in vitro. In vivo, we demonstrated that basal Ebp1 phosphorylation was dependent upon PKC. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249093 |
Thr366 |
QSSASRKtQKKKKKK |
Homo sapiens |
|
| pmid |
sentence |
| 11325528 |
We found that Ebp1 was basally phosphorylated in AU565 breast cancer cells on serine/threonine residues and that this phosphorylation was enhanced by heregulin treatment. Both serine and threonine residues of a GST-Ebp1 fusion protein were phosphorylated by PKC in vitro. In vivo, we demonstrated that basal Ebp1 phosphorylation was dependent upon PKC. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKCA |
phosphorylation
|
PA2G4 |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249089 |
Ser363 |
ALLQSSAsRKTQKKK |
Homo sapiens |
|
| pmid |
sentence |
| 11325528 |
We found that Ebp1 was basally phosphorylated in AU565 breast cancer cells on serine/threonine residues and that this phosphorylation was enhanced by heregulin treatment. Both serine and threonine residues of a GST-Ebp1 fusion protein were phosphorylated by PKC in vitro. In vivo, we demonstrated that basal Ebp1 phosphorylation was dependent upon PKC. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249092 |
Thr366 |
QSSASRKtQKKKKKK |
Homo sapiens |
AU-565 Cell |
| pmid |
sentence |
| 11325528 |
We found that Ebp1 was basally phosphorylated in AU565 breast cancer cells on serine/threonine residues and that this phosphorylation was enhanced by heregulin treatment. Both serine and threonine residues of a GST-Ebp1 fusion protein were phosphorylated by PKC in vitro. In vivo, we demonstrated that basal Ebp1 phosphorylation was dependent upon PKC. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PAK1 | up-regulates
phosphorylation
|
PA2G4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160963 |
Thr261 |
QYGLKMKtSRAFFSE |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 18283314 |
We found that pak1 phosphorylated ebp1 in vitro and mapped the phosphorylation site to threonine 261. these studies demonstrate for the first time that ebp1 is a substrate of pak1 and the importance of the pak1 phosphorylation site for the functional activity of ebp1 in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PA2G4 | down-regulates quantity by repression 
transcriptional regulation
|
KLK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253662 |
|
|
|
|
| pmid |
sentence |
| 16254079 |
Ectopic expression of ebp1, a member of the PA2G4 family, inhibits the proliferation and induces the differentiation of human breast and prostate cancer cell lines. Ebp1 inhibits transcription of E2F1 and androgen receptor regulated genes such as prostate specific antigen (PSA) through its interactions with histone deacetylases (HDACs) |
|
| Publications: |
1 |
3.0
PA2G4
- 
- 