Summary

Name CTNND2
Full Name Catenin delta-2
Synonyms Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin | NPRAP
Primary ID Q9UQB3
Links - -
Type protein
Relations 8
Function Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png binding CDH3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTNND2 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTNND2 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTNND2 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding ERBIN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding CDH2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding CDH5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding CDH1 0.14
Publications: 1 Organism: Homo Sapiens