| + |
HIPK2 | up-regulates activity 
phosphorylation
|
PAX6 |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251269 |
Thr281 |
QRRQASNtPSHIPIS |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 16407227 |
HIPK2 phosphorylates the activation domain of Pax6, which augments Pax6 transactivation by enhancing its interaction with p300. Mass spectrometric analysis identified three Pax6 phosphorylation sites as threonines 281, 304, and 373. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251270 |
Thr304 |
QPIPQPTtPVSSFTS |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 16407227 |
HIPK2 phosphorylates the activation domain of Pax6, which augments Pax6 transactivation by enhancing its interaction with p300. Mass spectrometric analysis identified three Pax6 phosphorylation sites as threonines 281, 304, and 373. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251271 |
Thr373 |
GRSYDTYtPPHMQTH |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 16407227 |
HIPK2 phosphorylates the activation domain of Pax6, which augments Pax6 transactivation by enhancing its interaction with p300. Mass spectrometric analysis identified three Pax6 phosphorylation sites as threonines 281, 304, and 373. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates quantity by repression 
transcriptional regulation
|
PAX6 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251874 |
|
|
Homo sapiens |
Lens Epithelial Cell Line |
| pmid |
sentence |
| 17251190 |
The effect of TGFbeta on Pax6 expression was studied in the FHL124 lens epithelial cell line and was found to cause up to a 50% reduction in Pax6 mRNA levels within 24 h. Pax6-stimulated activity of the Pax6 promoter is repressed by TGFβ signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU5F1 | down-regulates quantity by repression
transcriptional regulation
|
PAX6 |
0.454 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253163 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 22795133 |
Knockdown of Oct4 or Nanog induced an increase in the expression of Pax6, Gata4, Gata6, Sox17, and FoxA2 in E, H, and p21KD MSCs ( Figure 3F and Figure S2D) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NANOG | down-regulates quantity by repression
transcriptional regulation
|
PAX6 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253164 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 22795133 |
Knockdown of Oct4 or Nanog induced an increase in the expression of Pax6, Gata4, Gata6, Sox17, and FoxA2 in E, H, and p21KD MSCs ( Figure 3F and Figure S2D) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX6 | up-regulates quantity by expression 
transcriptional regulation
|
PAX6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251873 |
|
|
Homo sapiens |
Lens Epithelial Cell Line |
| pmid |
sentence |
| 17251190 |
Pax6-stimulated activity of the Pax6 promoter is repressed by TGFβ signalling. TGFβ receptor activation represses Pax6 promoter activity by releasing Pax6 from autoregulating its own promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PDHX | down-regulates activity 
binding
|
PAX6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254903 |
|
|
Homo sapiens |
BHK-21 Cell |
| pmid |
sentence |
| 12783165 |
In the heterologous cell line BHK-21, Pdx1 inhibited by 60 to 80% the activation of the alpha-cell specific element G1 conferred by Pax-6 and/or Cdx-2/3. Although Pdx1 could bind three AT-rich motifs within G1, two of which are binding sites for Pax-6 and Cdx-2/3, the affinity of Pdx1 for G1 was much lower as compared to Pax-6. In addition, Pdx1 inhibited Pax-6 mediated activation through G3, to which Pdx1 was unable to bind. Moreover, a mutation impairing DNA binding of Pdx1 had no effect on its inhibition on Cdx-2/3. Since Pdx1 interacts directly with Pax-6 and Cdx-2/3 forming heterodimers, we suggest that Pdx1 inhibits glucagon gene transcription through protein to protein interactions with Pax-6 and Cdx-2/3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX6 | form complex 
binding
|
CDX2/PAX6/P300 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70963 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10506141 |
In the present study, we investigated the interaction of cdx-2 and pax-6 with p300, a co-activator coupled to the basal transcription machinery. In transient transfection-expression experiments, we found that the transactivating effects of cdx-2 and pax-6 on the glucagon gene were greatly enhanced by the additional expression of p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX6 | up-regulates quantity by expression
transcriptional regulation
|
CTNND2 |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251878 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16973151 |
In Pax6 mutant embryos, delta-catenin expression was severely reduced in the optic vesicle neural ectoderm, in the ventricular zone of the neocortex and in the external granule layer of the cerebellum. We identified a Pax6 binding site in delta-catenin promoter that is conserved between mice and humans and which is effectively bound by Pax6 in vitro. Our results suggest that Pax6 regulates delta-catenin expression during CNS development in mice. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PAX6 | up-regulates quantity by expression
transcriptional regulation
|
GCG |
0.609 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254905 |
|
|
Homo sapiens |
BHK-21 Cell |
| pmid |
sentence |
| 12783165 |
In the heterologous cell line BHK-21, Pdx1 inhibited by 60 to 80% the activation of the alpha-cell specific element G1 conferred by Pax-6 and/or Cdx-2/3. Although Pdx1 could bind three AT-rich motifs within G1, two of which are binding sites for Pax-6 and Cdx-2/3, the affinity of Pdx1 for G1 was much lower as compared to Pax-6. In addition, Pdx1 inhibited Pax-6 mediated activation through G3, to which Pdx1 was unable to bind. Moreover, a mutation impairing DNA binding of Pdx1 had no effect on its inhibition on Cdx-2/3. Since Pdx1 interacts directly with Pax-6 and Cdx-2/3 forming heterodimers, we suggest that Pdx1 inhibits glucagon gene transcription through protein to protein interactions with Pax-6 and Cdx-2/3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX6 | up-regulates quantity by expression
transcriptional regulation
|
PCSK1 |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254900 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19034419 |
PAX6 can bind to the promoter and directly upregulate production of prohormone convertase (PC)1/3, an enzyme essential for conversion of proinsulin to insulin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD3 | down-regulates activity
binding
|
PAX6 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251875 |
|
|
Homo sapiens |
Lens Epithelial Cell Line |
| pmid |
sentence |
| 17251190 |
The paired domain of Pax6 interacts with the MH1 domain of Smad3. Smad3 prevents Pax6 paired domain from binding DNA |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PAX6
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