3.0
Summary
| Name |  SMC3View Modifications |
| Full Name | Structural maintenance of chromosomes protein 3 |
| Synonyms | SMC protein 3, SMC-3, Basement membrane-associated chondroitin proteoglycan, Bamacan, Chondroitin sulfate proteoglycan 6, Chromosome-associated polypeptide, hCAP | BAM, BMH, CSPG6, SMC3L1 |
| Primary ID | Q9UQE7 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 |
phosphorylation
|
SMC3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK2A2 |
phosphorylation
|
SMC3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATM |
phosphorylation
|
SMC3 | 0.732 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMC3 | form complex 
binding
|
Cohesin complex | 0.908 |
| Publications: | 1 | |||
| + | SMC3 | form complex
binding
|
RAD21L Cohesin complex | 0.814 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Tissue: | Gonad | |||
| + | SMC3 | down-regulates activity 
binding
|
MXD1 | 0.3 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | SMC3 | down-regulates activity
binding
|
MXD3 | 0.3 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | SMC3 | down-regulates activity
binding
|
MXD4 | 0.3 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | SMC3 | down-regulates activity
binding
|
MXI1 | 0.413 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |