Summary

Name SMC3
Full Name Structural maintenance of chromosomes protein 3
Synonyms SMC protein 3, SMC-3, Basement membrane-associated chondroitin proteoglycan, Bamacan, Chondroitin sulfate proteoglycan 6, Chromosome-associated polypeptide, hCAP | BAM, BMH, CSPG6, SMC3L1
Primary ID Q9UQE7
Links - -
Type protein
Relations 9
Function Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CSNK2A2 img/unknown.png phosphorylation SMC3 0.2
Publications: 1 Organism: Homo Sapiens
+ CSNK2A1 img/unknown.png phosphorylation SMC3 0.2
Publications: 1 Organism: Homo Sapiens
+ ATM img/unknown.png phosphorylation SMC3 0.732
Publications: 1 Organism: Homo Sapiens
+ SMC3form complex img/form-complex.png binding Cohesin complex 0.908
Publications: 1
+ SMC3down-regulates activity img/direct_inhibition.png binding MXD4 0.3
Publications: 1 Organism: Chlorocebus Aethiops
+ SMC3down-regulates activity img/direct_inhibition.png binding MXI1 0.413
Publications: 1 Organism: Chlorocebus Aethiops
+ SMC3down-regulates activity img/direct_inhibition.png binding MXD1 0.3
Publications: 1 Organism: Chlorocebus Aethiops
+ SMC3down-regulates activity img/direct_inhibition.png binding MXD3 0.3
Publications: 1 Organism: Chlorocebus Aethiops
+ SMC3form complex img/form-complex.png binding RAD21L Cohesin complex 0.814
Publications: 1 Organism: Mus Musculus
Tissue: Gonad