3.0
Summary
| Name |  PTPN22View Modifications |
| Full Name | Tyrosine-protein phosphatase non-receptor type 22 |
| Synonyms | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP, PEST-domain phosphatase, PEP | PTPN8 |
| Primary ID | Q9Y2R2 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCD | down-regulates 
phosphorylation
|
PTPN22 | 0.318 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN22 | down-regulates
dephosphorylation
|
CBL | 0.395 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN22 | down-regulates activity
dephosphorylation
|
LCK | 0.741 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN22 | down-regulates
dephosphorylation
|
LCK | 0.741 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN22 | down-regulates activity
dephosphorylation
|
ZAP70 | 0.693 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN22 | down-regulates
dephosphorylation
|
ZAP70 | 0.693 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN22 | down-regulates activity
dephosphorylation
|
CD247 | 0.458 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN22 | up-regulates activity 
dephosphorylation
|
NLRP3 | 0.364 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN22 | down-regulates
dephosphorylation
|
CD247 | 0.458 |
| Publications: | 1 | Organism: | Homo Sapiens | |