| + |
CSNK1E | up-regulates activity 
phosphorylation
|
APC |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109660 |
Ser1279 |
SRCSSLSsLSSAEDE |
Homo sapiens |
SW-480 Cell |
| pmid |
sentence |
| 11487578 |
Apc can be phosphorylated by ck1epsilon at ser1279 and ser1392. Mutation of conserved serine residues in the beta-catenin regulatory motifs of APC interfered with both axin-dependent phosphorylation and phosphorylation by CKIepsilon and impaired the ability of APC to regulate beta-catenin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109664 |
Ser1392 |
SRCTSVSsLDSFESR |
Homo sapiens |
SW-480 Cell |
| pmid |
sentence |
| 11487578 |
Apc can be phosphorylated by ck1epsilon at ser1279 and ser1392. Mutation of conserved serine residues in the beta-catenin regulatory motifs of APC interfered with both axin-dependent phosphorylation and phosphorylation by CKIepsilon and impaired the ability of APC to regulate beta-catenin. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates activity 
phosphorylation
|
APC |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250335 |
Ser2054 |
MPKKKKPsRLKGDNE |
Homo sapiens |
|
| pmid |
sentence |
| 11050185 |
Changing a serine residue (Ser(2054)) to aspartic acid mutated the potential protein kinase A site adjacent to NLS2(APC), resulting in both inhibition of the NLS2(APC)-mediated nuclear import of a chimeric beta-galactosidase fusion protein and a reduction of full-length APC nuclear localization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APC | down-regulates quantity by repression
transcriptional regulation
|
ODC1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12112318 |
APC-dependent regulation of ornithine decarboxylase in human colon tumor cells|Upon induction of APC expression, ODC promoter activity and RNA levels were suppressed |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AXIN1 | up-regulates activity
binding
|
APC |
0.943 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60043 |
|
|
Homo sapiens |
SW-480 Cell |
| pmid |
sentence |
| 9734785 |
Axin, an inhibitor of the wnt pathway, interacts with beta-catenin, gsk-3beta and apc and reduces the beta-catenin level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AXIN2 | up-regulates
binding
|
APC |
0.833 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79944 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10911903 |
It has been found that a multiprotein complex assembled by the cytoplasmic component conductin induces degradation of cytoplasmic beta-catenin. The complex includes apc, the serine/threonine kinase gsk3 beta, and beta-catenin, which bind to conductin at distinct domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Kidney, Lung |
| + |
KRT1 | up-regulates activity
phosphorylation
|
APC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251879 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18359618 |
Phosphorylation of this central repeat region of APC significantly enhances its affinity for β-catenin. When the repeats are phosphorylated by the cooperative action of CK1 and GSK3β, the binding interaction is significantly altered and enhanced. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | up-regulates
phosphorylation
|
APC |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75366 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10698523 |
Gsk-3beta-dependent phosphorylation of apc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL1 | down-regulates activity
binding
|
APC |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167951 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10330181 |
Dvl-1 inhibits Axin-promoted GSK-3_-dependent phosphorylation of _-catenin and APC, leading to beta-catenin stabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHRNB3 | up-regulates activity
binding
|
APC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264261 |
|
|
Homo sapiens |
Striated Muscle Cell |
| pmid |
sentence |
| 14502292 |
Treatment of muscle cells with neural agrin causes tyrosine phosphorylation of the AChR β subunit and induces AChR clustering by promoting anchoring of the receptor protein to postsynaptic cytoskeleton. Regulation of acetylcholine receptor clustering by the tumor suppressor APC. By showing a direct requirement for APC in AChR clustering, our present study suggests that the Wnt/β-catenin pathway may crosstalk with the agrin signaling cascade during the formation of mammalian neuromuscular junction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APC | down-regulates quantity
binding
|
CTNNB1 |
0.918 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177230 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22083140 |
Apc binds to both b-catenin and axin, and could shuttle b-catenin from the plasma membrane and nucleus to the cytoplasmic axin complex. APC cooperates with Axin to promote the phosphorylation of _-catenin by GSK3 [which requires priming phosphorylation by casein kinase 1, _-isoform (CK1_)]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDC14B | up-regulates
dephosphorylation
|
APC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179636 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18662541 |
The phosphatase cdc14b translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase apc/ccdh1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APC | form complex 
binding
|
SCF(TBL1) |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271949 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20181957 |
Upon UV-induced DNA damage, beta-catenin is recruited for polyubiquitination and subsequent proteasomal degradation by a unique, p53-induced SCF-like complex (SCF(TBL1)), comprised of Siah-1, Siah-1-interacting protein (SIP), Skp1, transducin beta-like 1 (TBL1), and adenomatous polyposis coli (APC). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMER1 | up-regulates
relocalization
|
APC |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199375 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Apc membrane recruitment protein 1 (amer1;alsoknownas wtx) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APC | form complex
binding
|
GSK3B/Axin/APC |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227296 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9734785 |
Axin, an inhibitor of the wnt pathway, interacts with beta-catenin, gsk-3beta and apc and reduces the beta-catenin level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
APC
- 
- 