| + |
CDX2/PAX6/P300 | up-regulates quantity by expression 
transcriptional regulation
|
GCG |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10506141 |
Pax-6 and cdx-2 also directly interacted with one another at the protein level. pax-6, bound to its dna recognition site in the glucagon g1 promoter element, tethered cdx-2 to the molecular complex of pax-6 and p300. Further, we found that the presence of cdx-2 enhanced the interaction of pax-6 with p300, thus establishing a molecular complex of transcription factors implicated in tissue-specific glucagon gene expression with the basal transcriptional machinery. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDX2 | form complex 
binding
|
CDX2/PAX6/P300 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10506141 |
In the present study, we investigated the interaction of cdx-2 and pax-6 with p300, a co-activator coupled to the basal transcription machinery. In transient transfection-expression experiments, we found that the transactivating effects of cdx-2 and pax-6 on the glucagon gene were greatly enhanced by the additional expression of p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EP300 | form complex
binding
|
CDX2/PAX6/P300 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70960 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10506141 |
In the present study, we investigated the interaction of cdx-2 and pax-6 with p300, a co-activator coupled to the basal transcription machinery. In transient transfection-expression experiments, we found that the transactivating effects of cdx-2 and pax-6 on the glucagon gene were greatly enhanced by the additional expression of p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX6 | form complex
binding
|
CDX2/PAX6/P300 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70963 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10506141 |
In the present study, we investigated the interaction of cdx-2 and pax-6 with p300, a co-activator coupled to the basal transcription machinery. In transient transfection-expression experiments, we found that the transactivating effects of cdx-2 and pax-6 on the glucagon gene were greatly enhanced by the additional expression of p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CDX2/PAX6/P300