| + |
gamma-aminobutyric acid | up-regulates activity 
chemical activation
|
GABA-B receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263795 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9872316 |
GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic (GABA(A/C)) receptors to produce fast synaptic inhibition and metabotropic (GABA(B)) receptors to produce slow, prolonged inhibitory signals. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264962 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18790874 |
Gamma-Aminobutyric acid (GABA1), the major inhibitory neurotransmitter in the brain, exerts its action via ionotropic GABAA and metabotropic GABAB receptors. GABAA receptors (GABAA-Rs) are the major inhibitory receptors in the central nervous system (CNS). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
GABBR1 | form complex 
binding
|
GABA-B receptor |
0.678 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263742 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9872316 |
Heterodimerization is required for the formation of a functional GABA(B) receptor.|These results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GABBR2 | form complex
binding
|
GABA-B receptor |
0.678 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263743 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9872316 |
Heterodimerization is required for the formation of a functional GABA(B) receptor.|These results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GABA-B receptor | up-regulates activity
binding
|
GNB/GNG |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265068 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20655485 |
The main G b/g-dependent effectors of presynaptic GABAB receptors are P/Q-and N-type voltage-dependent Ca2+ channels. GABAB receptors inhibit these Ca2+ channels at excitatory and inhibitory terminals, thereby restricting neurotransmitter release. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
GABA-B receptor | down-regulates 
|
Excitatory_synaptic_transmission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263794 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9872316 |
GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic (GABA(A/C)) receptors to produce fast synaptic inhibition and metabotropic (GABA(B)) receptors to produce slow, prolonged inhibitory signals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Central Nervous System |
| Pathways: | GABAergic synapse |
| + |
GABA-B receptor | up-regulates activity
binding
|
GNB5 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265064 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30541966 |
GABAB receptors are G protein-coupled receptors that mediate slow and prolonged inhibitory action, via activation of Gαi/o-type proteins. GABAB receptors mediate their inhibitory action through activating inwardly rectifying K+ channels, inactivating voltage-gated Ca2+ channels, and inhibiting adenylate cyclase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
GABA-B receptor | up-regulates activity
binding
|
GNAI1 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264965 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30541966 |
GABAB receptors are G protein-coupled receptors that mediate slow and prolonged inhibitory action, via activation of Gαi/o-type proteins. GABAB receptors mediate their inhibitory action through activating inwardly rectifying K+ channels, inactivating voltage-gated Ca2+ channels, and inhibiting adenylate cyclase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GABA-B receptor
CPX-2955