| + |
KAT6A/KAT6B | up-regulates 
acetylation
|
TP53 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217194 |
Lys120 |
FLHSGTAkSVTCTYS |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 23431171 |
We show here that moz is an acetyltransferase of p53 at k120 and k382 and colocalizes with p53 in promyelocytic leukemia (pml) nuclear bodies following cellular stress. The moz-pml-p53 interaction enhances moz-mediated acetylation of p53, and this ternary complex enhances p53-dependent p21 expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217198 |
Lys382 |
QSTSRHKkLMFKTEG |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 23431171 |
We show here that moz is an acetyltransferase of p53 at k120 and k382 and colocalizes with p53 in promyelocytic leukemia (pml) nuclear bodies following cellular stress. The moz-pml-p53 interaction enhances moz-mediated acetylation of p53, and this ternary complex enhances p53-dependent p21 expression |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT6A/KAT6B | up-regulates
binding
|
RUNX1 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217201 |
|
|
Homo sapiens |
Macrophage, Leukemia Cell, Monocyte |
| pmid |
sentence |
| 11742995 |
The activation domain of aml1 is required for its interaction with moz / moz activates aml1_mediated transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT6B | form complex 
binding
|
KAT6A/KAT6B |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17694082 |
Like gcn5/pcaf and p300/cbp, moz and morf are transcriptional co-activators with intrinsic hat activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT6A | form complex
binding
|
KAT6A/KAT6B |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157304 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 17694082 |
Like gcn5/pcaf and p300/cbp, moz and morf are transcriptional co-activators with intrinsic hat activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT6A/KAT6B | up-regulates
binding
|
RUNX2 |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217204 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell, Lymphoma Cell |
| pmid |
sentence |
| 11965546 |
Moz and morf both interact with runx2 / while morf does not acetylate runx2, its sm domain potentiates runx2-dependent transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KAT6A/KAT6B