| + |
CDK16 | down-regulates quantity 
phosphorylation
|
CDKN1B |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278214 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
|
| pmid |
sentence |
| 25205104 |
Experimentally overexpressing PCTAIRE1 in these cells caused p27 Ser10 phosphorylation , and reduced p27 protein levels in a proteasome dependent manner .|PCTAIRE1 phosphorylates p27 at Ser 10. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK16 | down-regulates quantity by destabilization
phosphorylation
|
CDKN1B |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273016 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25205104 |
In vitro kinase assays showed PCTAIRE1 phosphorylates p27 at Ser10. PCTAIRE1 silencing modulated Ser10 phosphorylation on p27 and led to its accumulation in cancer cells but not in nontransformed cells.|Together our findings reveal an unexpected role for PCTAIRE1 in regulating p27 stability, mitosis, and tumor growth, suggesting PCTAIRE1 as a candidate cancer therapeutic target. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates
phosphorylation
|
CDK16 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191623 |
Ser153 |
SRRLRRVsLSEIGFG |
Homo sapiens |
|
| pmid |
sentence |
| 22184064 |
Here, we report that cdk16 is activated by membrane-associated cyclin y (ccny). Treatment of transfected human cells with the protein kinase a (pka) activator forskolin blocked, while kinase inhibition promoted, ccny-dependent targeting of cdk16-green fluorescent protein (gfp) to the cell membrane. Ccny binding to cdk16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential pka phosphorylation site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
CDK16 | down-regulates activity
phosphorylation
|
TP53 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278354 |
Ser315 |
LPNNTSSsPQPKKKP |
Homo sapiens |
|
| pmid |
sentence |
| 29344296 |
In this study, we demonstrated that CDK16 phosphorylates p53 at Ser315 and promotes ubiquitination and subsequent degradation of p53.|Together, these results suggest that CDK16 negatively regulates p53 stability at the post-translational level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinY/CDK16 | up-regulates activity 
phosphorylation
|
CDK16 |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273006 |
Ser336 |
PPDILLGsTDYSTQI |
|
|
| pmid |
sentence |
| 32723157 |
Mechanistically the S326 phosphorylation by AMPK promotes the interaction of CCNY with CDK16, which in turn autophosphorylates S336, which serves as a marker for active CCNY-CDK16. |
|
| Publications: |
1 |
| + |
CDK16 | down-regulates activity
phosphorylation
|
NSF |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279511 |
Ser569 |
FPFIKICsPDKMIGF |
Homo sapiens |
|
| pmid |
sentence |
| 16461345 |
Moreover, inhibition of Pctaire1 activity by transfecting its kinase-dead (KD) mutant into COS-7 cells enhances the self association of NSF.|We demonstrate that the D2 domain of NSF, which is required for the oligomerization of NSF subunits, binds directly to and is phosphorylated by Pctaire1 on serine 569. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK16 | up-regulates activity
phosphorylation
|
PRKAR1A |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273018 |
Ser83 |
DSREDEIsPPPPNPV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25605337 |
PCTK1 regulates spindle orientation in a kinase-dependent manner. Phosphoproteomic analysis together with an RNA interference screen revealed that PCTK1 regulates spindle orientation through phosphorylation of Ser83 on KAP0, a regulatory subunit of protein kinase A (PKA) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK16 | up-regulates activity
phosphorylation
|
PRC1 |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273017 |
Thr481 |
RRGLAPNtPGKARKL |
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 35449080 |
Mechanistically, CDK16 exerts its function by phosphorylating protein regulator of cytokinesis 1 (PRC1) to regulate spindle formation during mitosis.|Indeed, immunoblot analysis showed that PRC1 phosphorylation at the T481 site (CDK-dependent major phosphorylation site) fluctuated with the abundance of CDK16 protein in the cell cycle process |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5 | up-regulates activity
phosphorylation
|
CDK16 |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12084709 |
Taken together, our findings demonstrate that Pctaire1 interacts with p35, both in vitro and in vivo, and that phosphorylation of Pctaire1 by Cdk5 enhances its kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK16 | form complex 
binding
|
CyclinY/CDK16 |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273003 |
|
|
|
|
| pmid |
sentence |
| 30992425 |
CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). |
|
| Publications: |
1 |
| + |
dabrafenib | down-regulates activity
chemical inhibition
|
CDK16 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261073 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29112787 |
We have identified dabrafenib as a potent inhibitor of NEK9 and CDK16, and our studies suggest that inhibition of these kinases may have activity against cancers that do not harbor BRAF mutations. We confirmed NEK9 to be a potent target of dabrafenib by in vitro kinase assays, with inhibition of NEK9 observed in the single-digit nanomolar range. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDK16
- 
- 