3.0
Summary
| Name |  CDK16View Modifications |
| Full Name | Cyclin-dependent kinase 16 |
| Synonyms | Cell division protein kinase 16, PCTAIRE-motif protein kinase 1, Serine/threonine-protein kinase PCTAIRE-1 | PCTAIRE1, PCTK1 |
| Primary ID | Q00536 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Inhibitors | dabrafenib |
| Function | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK16 | down-regulates quantity by destabilization 
phosphorylation
|
CDKN1B | 0.338 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKACA | down-regulates
phosphorylation
|
CDK16 | 0.319 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | CyclinY/CDK16 | up-regulates activity 
phosphorylation
|
CDK16 | 0.691 |
| Publications: | 1 | |||
| + | CDK16 | up-regulates activity
phosphorylation
|
PRKAR1A | 0.275 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK16 | up-regulates activity
phosphorylation
|
PRC1 | 0.35 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | dabrafenib | down-regulates activity
chemical inhibition
|
CDK16 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK16 | form complex 
binding
|
CyclinY/CDK16 | 0.691 |
| Publications: | 1 | |||