Relation Results

Summary

Name SUZ12/EZH2
Primary ID SIGNOR-C77
Type complex
Formed by SUZ12, EZH2
Relations 5

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Type: Score: Layout: SPV 
0.9610.3740.8470.9610.733EZH2SUZ12/EZH2MAPK14SUZ12/EZH2/YY1SUZ12YY1

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Relations
Regulator
Mechanism
target
score ℹ
+ EZH2form complex img/form-complex.png binding SUZ12/EZH2 0.961
Identifier Residue Sequence Organism Cell Line
SIGNOR-146758 Homo sapiens
pmid sentence
Suz12 is a polycomb group protein that forms polycomb repressive complexes (prc2/3) together with eed and histone methyltransferase ezh2.
Publications: 1 Organism: Homo Sapiens
+ MAPK14up-regulates img/direct-activation.png phosphorylation SUZ12/EZH2 0.374
Identifier Residue Sequence Organism Cell Line
SIGNOR-217676 Homo sapiens
pmid sentence
P38 can phosphorylate the histone-lysine n-methyltransferase ezh2, the catalytic subunit of the polycomb repressive complex 2 (prc2), with phosphorylation of ezh2 necessary for prc2s association with the transcriptional repressor yy1 and subsequent chromatin remodelling.
Publications: 1 Organism: Homo Sapiens
+ SUZ12/EZH2form complex img/form-complex.png binding SUZ12/EZH2/YY1 0.847
Identifier Residue Sequence Organism Cell Line
SIGNOR-235577 Mus musculus C2C12 Cell, Satellite Cell
pmid sentence
TNF-activated p38a kinase promotes the interaction between YY1 and PRC2, via threonine 372 phosphorylation of EZH2, the enzy- matic subunit of the complex, leading to the for- mation of repressive chromatin on Pax7 promoter.
Publications: 1 Organism: Mus Musculus
+ SUZ12form complex img/form-complex.png binding SUZ12/EZH2 0.961
Identifier Residue Sequence Organism Cell Line
SIGNOR-146764 Homo sapiens
pmid sentence
Suz12 is a polycomb group protein that forms polycomb repressive complexes (prc2/3) together with eed and histone methyltransferase ezh2.
Publications: 1 Organism: Homo Sapiens
+ SUZ12/EZH2up-regulates activity img/direct-activation.png binding YY1 0.733
Identifier Residue Sequence Organism Cell Line
SIGNOR-235574 Mus musculus C2C12 Cell, Satellite Cell
pmid sentence
TNF-activated p38a kinase promotes the interaction between YY1 and PRC2, via threonine 372 phosphorylation of EZH2, the enzy- matic subunit of the complex, leading to the for- mation of repressive chromatin on Pax7 promoter.
Publications: 1 Organism: Mus Musculus
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