Summary

Name SMURF1
Full Name E3 ubiquitin-protein ligase SMURF1
Synonyms hSMURF1, HECT-type E3 ubiquitin transferase SMURF1, SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1 | KIAA1625
Primary ID Q9HCE7
Links - -
Type protein
Relations 21
Function E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png transcriptional regulation SMURF1
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination SMAD9
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination SMAD1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination BMPR1A
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination SMAD5
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DAB2IP 0.46
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination RUNX2 0.23
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization SMAD6 0.89
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD4 0.37
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding PARD6/SMURF1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization SMURF1 0.86
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD7 0.86
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR2 0.21
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination BMPR2 0.37
Publications: 2 Organism: Homo Sapiens