| + |
9-cis-retinoic acid | up-regulates activity 
chemical activation
|
RXR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259240 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18321241 |
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAR | up-regulates activity
binding
|
RXR |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256198 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Cellular responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct families of receptors: the retinoic acid receptors (RAR) and the retinoid X receptors (RXR). Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer |
| + |
all-trans-retinoic acid | up-regulates activity
chemical activation
|
RXR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256190 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17132853 |
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer |
| + |
RXR | up-regulates activity
binding
|
RAR |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Cellular responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct families of receptors: the retinoic acid receptors (RAR) and the retinoid X receptors (RXR). Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer |
| + |
bexarotene | up-regulates activity
chemical activation
|
RXR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259233 |
|
|
Homo sapiens |
Non-small Cell Lung Cancer Cell |
| pmid |
sentence |
| 17483357 |
Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXR | up-regulates activity
binding
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259057 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer |
3.0
RXR