Summary

Name RXRA
Full Name Retinoic acid receptor RXR-alpha
Synonyms Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha | NR2B1
Primary ID P19793
Links - -
Type protein
Relations 34
Pathways Acute Myeloid Leukemia, ASXL1 in AML
Inhibitors [5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid; sulindac
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RXRA 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARG 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARD 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1B 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding RARG 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PML-RARalpha 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png binding RXRA 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates img/direct-activation.png binding THRA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding THRB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARA 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.6
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates img/direct-activation.png binding NR1H2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RXRA 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARA 0.52
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ down-regulates activity img/direct_inhibition.png chemical inhibition RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARB 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation RXRA 0.14
Publications: 1 Organism: Homo Sapiens