Relation Results

Summary

Name mir-10b
Primary ID URS00004CAC40_9606
Type miRNA
Links
Description Homo sapiens (human) microRNA hsa-mir-10b precursor
Relations 4
Pathways Acute Myeloid Leukemia, miRNA in AML

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Type: Score: Layout: SPV 
0.40.40.40.4Microprocessor complexmir-10bTWIST1CADM2DDX5

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Relations
Regulator
Mechanism
target
score ℹ
+ Microprocessor complexup-regulates quantity img/direct-activation.png post transcriptional regulation mir-10b 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-275661
pmid sentence
Both the phosphorylation and sumoylation of DDX5 enhance the formation of a DDX5/Drosha/DGCR8 complex, thus promoting microRNA-10b processing.
Publications: 1
+ TWIST1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation mir-10b 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-255887 Homo sapiens
pmid sentence
We then showed that ectopic expression of MLL fusion genes in both human and mouse normal hematopoietic stem/progenitor cells could significantly down-regulate endogenous expression of miR-495 and that the depletion of MLL fusions resulted in the up-regulation of miR-495. Thus, our data suggest that there is an MLL-fusion–mediated negative regulation of the production of miR-495 in hematopoietic cells.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ mir-10bdown-regulates quantity img/direct_inhibition.png destabilization CADM2 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-255794 Homo sapiens
pmid sentence
The down-regulation of miR-29b is thought to promote DNA hypermethylation in AML since miR-29b can directly target DNMT3A, DNMT3B, and Sp1 (a transcriptional regulator of DNMT2
Publications: 1 Organism: Homo Sapiens
+ DDX5up-regulates quantity img/direct-activation.png post transcriptional regulation mir-10b 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-275660
pmid sentence
Both the phosphorylation and sumoylation of DDX5 enhance the formation of a DDX5/Drosha/DGCR8 complex, thus promoting microRNA-10b processing.
Publications: 1
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