SARS-CoV FIBROSIS
Pathway ID: SIGNOR-SCFIView in NDEx
Description: Pulmonary fibrosis is a common consequence of SARS coronavirus (SARS-CoV) infection. Transforming growth factor-β1 (TGF-β1) is a crucial mediator of this phenomenon and causes tissue fibrosis by activating downstream small mother against decapentaplegic (Smad) signaling which triggers pro-fibrotic genes overexpression. Smad3 is the major downstream regulator that promote TGF-β mediated tissue fibrosis, while Smad7 protects against fibrosis inhibiting the TGF-β1/Smad pathway. The renin-angiotensin system (RAS) also controls the fibrotic process. The Spike-dependent down-regulation of ACE2 receptor decreases the Ang (1-7) level, upregulating the angiotensin-converting enzyme (ACE)- Ang II-angiotensin type 1 receptor (AT1R) signalling cascade, which in turn triggers inflammation and fibrosis in pulmonary tissue.
Curated by: Marta Iannuccelli
Description: Pulmonary fibrosis is a common consequence of SARS coronavirus (SARS-CoV) infection. Transforming growth factor-β1 (TGF-β1) is a crucial mediator of this phenomenon and causes tissue fibrosis by activating downstream small mother against decapentaplegic (Smad) signaling which triggers pro-fibrotic genes overexpression. Smad3 is the major downstream regulator that promote TGF-β mediated tissue fibrosis, while Smad7 protects against fibrosis inhibiting the TGF-β1/Smad pathway. The renin-angiotensin system (RAS) also controls the fibrotic process. The Spike-dependent down-regulation of ACE2 receptor decreases the Ang (1-7) level, upregulating the angiotensin-converting enzyme (ACE)- Ang II-angiotensin type 1 receptor (AT1R) signalling cascade, which in turn triggers inflammation and fibrosis in pulmonary tissue.
Curated by: Marta Iannuccelli
complexity level
| level 1 | seed interactions | |
| level 2 | connect | |
| level 3 | first neighbors | |
| level 4 | all | |
| level 5 | PPI |
30 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| NfKb-p65/p50 | SIGNOR-C13 |
| N | P59595 |
| S | P59594 |
| Apoptosis | SIGNOR-PH2 |
| ACE | P12821 |
| S | P0DTC2 |
| Angiotensin-1 | P01019-PRO_0000032457 |
| chloroquine | CHEBI:3638 |
| Inflammation | SIGNOR-PH12 |
| TGFb | SIGNOR-PF5 |
| Alamandine | CID:44192273 |
| CGP-42112A | CHEBI:147302 |
| Fibrosis | SIGNOR-PH90 |
| SMAD3 | P84022 |
| Angiotensin-2 | P01019-PRO_0000032458 |
| SERPINE1 | P05121 |
| REN | P00797 |
| MRGPRD | Q8TDS7 |
| Angiotensin 1-7 | P01019-PRO_0000420660 |
| SMAD3/SMAD4 | SIGNOR-C9 |
| MAS1 | P04201 |
| EP300 | Q09472 |
| ACE2 | Q9BYF1 |
| TGFBR2 | P37173 |
| AGTR2 | P50052 |
| SMAD7 | O15105 |
| AGTR1 | P30556 |
| BCL2L11 | O43521 |
| AGT | P01019 |
| TGFBR1 | P36897 |