| + |
STK19 | up-regulates activity 
phosphorylation
|
NRAS |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264566 |
Ser89 |
FAINNSKsFADINLY |
Homo sapiens |
SK-MEL-2 Cell |
| pmid |
sentence |
| 30712867 |
STK19 Phosphorylates NRAS Protein at Serine 89|STK19 phosphorylates NRAS to enhance its binding to its downstream effectors and promotes oncogenic NRAS-mediated melanocyte malignant transformation.| |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN11 | up-regulates activity
dephosphorylation
|
NRAS |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255754 |
Tyr32 |
QNHFVDEyDPTIEDS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26617336 |
Here we identify SHP2 as the ubiquitously expressed tyrosine phosphatase that preferentially binds to and dephosphorylates Ras to increase its association with Raf and activate downstream proliferative Ras/ERK/MAPK signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, AML_TRIPLETS, NPM1_new, Noonan syndrome |
| + |
NRAS | up-regulates
binding
|
ARAF |
0.828 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175216 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
The raf family of proteins (raf-1, a-raf, and b-raf) is serine/threonine kinases that bind to the effector region of ras-gtp, thus inducing translocation of the protein to the plasma membrane. Once there, raf proteins are activated and phosphorylated by different protein kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRAS | up-regulates activity
binding
|
BRAF |
0.849 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175219 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
The raf family of proteins (raf-1, a-raf, and b-raf) is serine/threonine kinases that bind to the effector region of ras-gtp, thus inducing translocation of the protein to the plasma membrane. Once there, raf proteins are activated and phosphorylated by different protein kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, AML_TRIPLETS, IL6 Signaling, Inhibition of Apoptosis, Malignant Melanoma, NPM1_new, Noonan syndrome |
| + |
NRAS | up-regulates 
|
GLI1 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17845852 |
Ras and akt signaling enhances the nuclear localization of gli1, counteracting its suppression by other modifiers that retain it in the cytoplasm, such as suppressor of fused (sufu) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRAS | up-regulates activity
binding
|
PI3K |
0.665 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252700 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner./lysine residue 227 is essential for the interaction of ras with pi3k |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, Onco-fusion proteins in AML, KIT in AML |
| + |
NRAS | up-regulates
binding
|
PIK3CG |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175228 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. It was also described that ras interacts with pi3k in a direct manner.llysine residue 227 is essential for the interaction of ras with pi3k |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRAS | up-regulates
binding
|
PIK3CB |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175225 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner./lysine residue 227 is essential for the interaction of ras with pi3k |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MVD | up-regulates quantity by stabilization
|
NRAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265889 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12646231 |
An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2. These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras. Ras and its oncogenic forms act as key players in controlling proliferation of normal and cancerous cells. Assigning mot-2 upstream of p21Ras offers an important mechanism for influence over cell proliferation. Therefore, we ra tionaled to investigate if overexpression of MPD could affect the steady state levels of Ras by affecting its prenylationTransient transfections of MPD-myc in COS 7 cells resulted in higher stable levels of Ras as compared to the untransfected cells (Fig. 3A, compare lanes 4 and 8 and Fig. 3B) |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
RASGEF1B | up-regulates
binding
|
NRAS |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161481 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19201597 |
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RASGEF1A | up-regulates
binding
|
NRAS |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19201597 |
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCR-ABL | up-regulates activity
|
NRAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261506 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8402896 |
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Mutation of Y177 to phenylalanine (Y177F) abolishes GRB-2 binding and abrogates BCR-ABL-induced Ras activation. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | Acute Myeloid Leukemia, Onco-fusion proteins in AML |
| + |
RASGEF1C | up-regulates
binding
|
NRAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19201597 |
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRAS | up-regulates activity
binding
|
PIK3CA |
0.837 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175222 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner./lysine residue 227 is essential for the interaction of ras with pi3k |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Malignant Melanoma |
| + |
RAPGEF6 | up-regulates
guanine nucleotide exchange factor
|
NRAS |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183799 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19201597 |
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOS1 | up-regulates activity
guanine nucleotide exchange factor
|
NRAS |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110566 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11560935 |
Sos and Ras-GRF are two families of guanine nucleotide exchange factors that activate Ras proteins in cells. Sos proteins are ubiquitously expressed and are activated in response to cell-surface tyrosine kinase stimulation Sos1 and Ras-GRF1 activate the Ras proteins Ha-Ras, N-Ras, and Ki-Ras |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175259 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, IL6 Signaling, Inhibition of Apoptosis, Malignant Melanoma, Noonan syndrome |
| + |
GOLGA7 | up-regulates activity
palmitoylation
|
NRAS |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261354 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16000296 |
Covalent lipid modifications mediate the membrane attachment and biological activity of Ras proteins. All Ras isoforms are farnesylated and carboxyl-methylated at the terminal cysteine; H-Ras and N-Ras are further modified by palmitoylation. Here we report that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes. DHHC9 is an integral membrane protein that contains a DHHC cysteine-rich domain. GCP16 encodes a Golgi-localized membrane protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AR | down-regulates quantity by repression 
transcriptional regulation
|
NRAS |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253676 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 16281084 |
After AR antagonist flutamide treatment, three hundred and twenty-six genes (3.93%) expressed differentially, 97 down-regulated and 219 up-regulated. Among them, eight up-regulated genes might be cell cycle-related, namely CDC10, NRAS, BTG1, Wee1, CLK3, DKFZP564A122, CDKN1A and BTG2. The CDKN1A and BTG1 gene mRNA expression was confirmed to be higher in the experimental group by RT-PCR, while p53 mRNA expression had no significant changes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAB2IP | down-regulates activity 
gtpase-activating protein
|
NRAS |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254747 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27858941 |
The GAP domain of DAB2IP is homologous to other Ras-GAPs, such as GAP120 and neurofibromin (NF1), and can stimulate the GTPase activity of RAS proteins both in vitro and in cancer cell lines. DAB2IP is able to stimulate in vitro and in vivo the GTPase activity of RAS proteins (H-Ras, K-Ras, and N-Ras) facilitating GTP hydrolysis to GDP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZDHHC9 | up-regulates activity
palmitoylation
|
NRAS |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261355 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16000296 |
Covalent lipid modifications mediate the membrane attachment and biological activity of Ras proteins. All Ras isoforms are farnesylated and carboxyl-methylated at the terminal cysteine; H-Ras and N-Ras are further modified by palmitoylation. Here we report that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes. DHHC9 is an integral membrane protein that contains a DHHC cysteine-rich domain. GCP16 encodes a Golgi-localized membrane protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRAS | up-regulates
relocalization
|
RAF1 |
0.865 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175231 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
The raf family of proteins (raf-1, a-raf, and b-raf) bind to the effector region of ras-gtp, thus inducing translocation of the protein to the plasma membrane. Once there, raf proteins are activated and phosphorylated by different protein kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Noonan syndrome |
| + |
RAPGEF5 | up-regulates
guanine nucleotide exchange factor
|
NRAS |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183738 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19201597 |
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NRAS
- 
- 