Summary

Name EIF4E
Full Name Eukaryotic translation initiation factor 4E
Synonyms eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein | EIF4EL1, EIF4F
Primary ID P06730
Links - -
Type protein
Relations 17
Pathways COVID-19 Causal Network, Insulin Signaling, Mitochondrial dynamics in T cell exhaustion, MTOR Signaling, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES
Inhibitors 4E2RCat
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation EIF4E 0.391
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation EIF4E 0.768
Publications: 3 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ img/unknown.png phosphorylation EIF4E 0.313
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation EIF4E 0.356
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation EIF4E 0.574
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation EIF4E 0.355
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES
+ down-regulates activity img/direct_inhibition.png binding EIF4E 0.645
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png translation regulation MTFP1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition EIF4E 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ up-regulates img/indirect-activation.png Protein_synthesis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES
+ up-regulates activity img/direct-activation.png binding EIF4E 0.797
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ form complex img/form-complex.png binding eIF4F_complex 0.838
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EIF4E 0.938
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES
+ up-regulates img/indirect-activation.png Translational_regulation 0.7
Publications: 1 Organism: Homo Sapiens