Summary

Name ATF4
Full Name Cyclic AMP-dependent transcription factor ATF-4
Synonyms cAMP-dependent transcription factor ATF-4, Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, Tax-responsive enhancer element-binding protein 67, TaxREB67 | CREB2, TXREB
Primary ID P18848
Links - -
Type protein
Relations 41
Pathways Aspartate and asparagine metabolism, COVID-19 Causal Network, SARS-CoV ER STRESS
Function Transcription factor that binds the cAMP response element (CRE) (consensus

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ATF4 0.625
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NLRP1 inflammasome 0.288
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination ATF4 0.335
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation ATF4 0.628
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation WARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DARS2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DDIT3 0.81
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPP1R15A 0.651
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FGF21 0.446
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation LARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HSPA5 0.656
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ASNS 0.638
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ATF4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation YARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATF4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation DYRK3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TARS2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ASNS 0.638
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATF4 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SIGMAR1 0.397
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation YARS2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATF4 0.628
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation EPRS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATF4 0.429
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation ATF4 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SARS2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CARS2 0.261
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation WARS2 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation AARS2 0.247
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FGF19 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation ATF4 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation AARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation LARS2 0.256
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NUPR1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NARS2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DDIT4 0.431
Publications: 1 Organism: Homo Sapiens