| + |
TAOK2 | up-regulates activity 
phosphorylation, binding
|
MAP2K3 |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106462 |
Ser218 |
ISGYLVDsVAKTMDA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11279118 |
Suggesting that tao2 selectively activates mek3 and mek6 of the p38 pathway in intact cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70947 |
|
|
in vitro |
|
| pmid |
sentence |
| 10497253 |
Cotransfection experiments suggested that tao2 selectively activates mek3 and mek6 but not meks 1, 4, or 7. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | P38 Signaling |
| + |
TAOK1 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60818 |
Ser218 |
ISGYLVDsVAKTMDA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9786855 |
The activation of and binding to MEK3 by TAO1 implicates TAO1 in the regulation of the p38-containing stress-responsive MAP kinase pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAP3K5 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161763 |
Ser218 |
ISGYLVDsVAKTMDA |
Homo sapiens |
|
| pmid |
sentence |
| 19920149 |
Ask1 is a member of a mapkkk family and functions as an upstream kinase engaged in c-jun nh2-terminal kinase (jnk)/p38 signaling via the phosphorylation and activation of mapkks, such as mkk3, -4, -6, and -7 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226672 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8974401 |
ASK1 activated SEK1 and MKK3 up to 7.0- and 11.8-fold, respectively |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling |
| + |
MAP3K3 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48625 |
Ser218 |
ISGYLVDsVAKTMDA |
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 9162092 |
These data indicate that mkk3 is preferentially activated by mekk3, whereas mkk4 is activated both by mekk2 and mekk3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K3 | up-regulates activity
phosphorylation
|
MAPK13 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273950 |
Thr180 |
RHADAEMtGYVVTRW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273949 |
Tyr182 |
ADAEMTGyVVTRWYR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP2K3 | up-regulates activity
phosphorylation
|
MAPK14 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40349 |
Thr180 |
RHTDDEMtGYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 8622669 |
Mkk3 is a protein kinase that phosphorylates and activates p38 map kinase but does not phosphorylate the related jnk or erk map kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40353 |
Tyr182 |
TDDEMTGyVATRWYR |
Homo sapiens |
|
| pmid |
sentence |
| 8622669 |
Mkk3 is a protein kinase that phosphorylates and activates p38 map kinase but does not phosphorylate the related jnk or erk map kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232156 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8622669 |
Mkk3 is a protein kinase that phosphorylates and activates p38 map kinase but does not phosphorylate the related jnk or erk map kinases. MKK3 is therefore a specific activator of p38 MAP kinase that is independent of the JNK and ERK signaling pathways. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236103 |
|
|
Homo sapiens |
Neutrophil, Macrophage, Monocyte |
| pmid |
sentence |
| 7535770 |
Recently, two map kinase kinases (mkk3 and mkk4) that activate p38 map kinase have been identified. the mechanism of p38 activation is mediated by dual phosphorylation on thr-180 and tyr-182. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling, TGF-beta Signaling, Toll like receptors |
| + |
MAP2K3 | up-regulates
phosphorylation
|
DYRK1B |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86731 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11980910 |
Mkk3 enhanced mirk kinase activity. Mkk3 possibly activates mirk by phosphorylating it. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
MAP2K3 | up-regulates activity
phosphorylation
|
p38 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260723 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236093 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 21902831 |
TAK1 can phosphorylate and activate MAP kinase kinase 3/6 (MKK3/6), and numerous studies have demonstrated a requirement for MKK3/6 activity in the initiation of myoblast differentiation, again in a p38-dependent manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42402 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17299140 |
Taken together, our data indicate that TAK1 and TAB1 play a pivotal role as upstream signal transducers activating the MKK3-p38 MAPK signaling cascade that leads to the induction of type I collagen expression by TGF-beta(1). In addition, our findings also suggest that TAK1 has a novel function in regulation of the steady-state protein levels of MKK3 and p38 MAPK. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors |
| + |
MAP2K3 | up-regulates
phosphorylation
|
MAPK12 |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83718 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
Mkk3, mkk4 and mkk6 all show a strong preference for phosphorylation of the tyrosine residue of the thr-gly-tyr motifs in their known substrates sapk2a/p38, sapk3/p38 gamma and sapk4/p38 delta. we therefore examined the phosphorylation of sapk2a/p38, sapk3/p38? And sapk4/p38? By mkk3, mkk4 and mkk6, which are all known to be capable of activating these enzymes in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45788 |
|
|
Homo sapiens |
COS-1 Cell |
| pmid |
sentence |
| 9003778 |
Immunoprecipitated mlk-3 catalyzed the phosphorylation of sek1 in vitro, and co-transfected mlk-3 induced phosphorylation of sek1 and mkk3 at sites required for activation, suggesting direct regulation of these protein kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K4 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.627 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-50891 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 9305639 |
These results, therefore, suggest that mtk1 directly phosphorylates and activates mkk3, mkk6 and sek1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
3.0
MAP2K3
- 
- 