| + |
MAPK1 | down-regulates 
phosphorylation
|
PPP2R5C |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144313 |
Ser337 |
QLAKCVSsPHFQVAE |
Homo sapiens |
|
| pmid |
sentence |
| 16456541 |
Iex-1 binds to b56 subunits and perk independently, enhances b56 phosphorylation by erk at a conserved ser/pro site in this complex and triggers dissociation from the catalytic subunit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates
phosphorylation
|
PPP2R5C |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144317 |
Ser337 |
QLAKCVSsPHFQVAE |
Homo sapiens |
|
| pmid |
sentence |
| 16456541 |
Iex-1 binds to b56 subunits and perk independently, enhances b56 phosphorylation by erk at a conserved ser/pro site in this complex and triggers dissociation from the catalytic subunit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R5C | up-regulates 
dephosphorylation
|
ATF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167560 |
Ser36 |
AQQVSSLsESEESQD |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
We propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. Pp2a/b56c antagonizes phosphorylation of atm sites in both creb and atf1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167564 |
Ser38 |
QVSSLSEsEESQDSS |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
We propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. Pp2a/b56c antagonizes phosphorylation of atm sites in both creb and atf5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167568 |
Ser41 |
SLSESEEsQDSSDSI |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
We propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. Pp2a/b56c antagonizes phosphorylation of atm sites in both creb and atf2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167572 |
Ser44 |
ESEESQDsSDSIGSS |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
We propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. Pp2a/b56c antagonizes phosphorylation of atm sites in both creb and atf4 |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
ATM | up-regulates activity
phosphorylation
|
PPP2R5C (isoform 1) |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276318 |
Ser520 |
CRADELAsQDGR |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 21460856 |
In the present study, we demonstrate that ataxia-telangiectasia mutated (ATM) directly phosphorylates and specifically regulates B56γ3, B56γ2 and B56δ, after DNA damage. We further show that phosphorylation of B56γ3 at Ser510 leads to an increase in B56γ3-PP2A complexes, and direction of PP2A phosphatase activity toward the substrate p53, activating its tumor-suppressive functions. we show that Ser510 phosphorylation significantly enhances the ability of B56γ3 to inhibit cell proliferation and anchorage-independent growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R5C | up-regulates quantity by stabilization
dephosphorylation
|
TP53 |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268154 |
Thr55 |
DDIEQWFtEDPGPDE |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 17245430 |
Ablation of the B56gamma protein by RNAi, which abolishes the Thr55 dephosphorylation in response to DNA damage, reduces p53 stabilization, Bax expression and cell apoptosis. To investigate the molecular mechanisms, we have shown that the endogenous B56gamma protein level and association with p53 increase after DNA damage. Finally, we demonstrate that Thr55 dephosphorylation is required for B56gamma3-mediated inhibition of cell proliferation and cell transformation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates
phosphorylation
|
PPP2R5C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270101 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16456541 |
Iex-1 binds to b56 subunits and perk independently, enhances b56 phosphorylation by erk at a conserved ser/pro site in this complex and triggers dissociation from the catalytic subunit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | down-regulates
phosphorylation
|
PPP2R5C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270196 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16456541 |
Iex-1 binds to b56 subunits and perk independently, enhances b56 phosphorylation by erk at a conserved ser/pro site in this complex and triggers dissociation from the catalytic subunit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R5C | up-regulates activity
binding
|
PPP2CA |
0.867 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268155 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7592815 |
We have identified by two-hybrid interaction a new human gene family encoding PP2A B subunits. This family, denoted B56, contains three distinct genes, one of which is differentially spliced. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R5C | down-regulates
binding
|
ERK1/2 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269922 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16456541 |
B56-containing pp2a dephosphorylate erk and their activity is controlled by the early gene iex-1 and erk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATM | up-regulates activity
phosphorylation
|
PPP2R5C (isoform 3) |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276320 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 21460856 |
In the present study, we demonstrate that ataxia-telangiectasia mutated (ATM) directly phosphorylates and specifically regulates B56γ3, B56γ2 and B56δ, after DNA damage. We further show that phosphorylation of B56γ3 at Ser510 leads to an increase in B56γ3-PP2A complexes, and direction of PP2A phosphatase activity toward the substrate p53, activating its tumor-suppressive functions. we show that Ser510 phosphorylation significantly enhances the ability of B56γ3 to inhibit cell proliferation and anchorage-independent growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R5C | down-regulates
binding
|
MAPK3 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144328 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16456541 |
B56-containing pp2a dephosphorylate erk and their activity is controlled by the early gene iex-1 and erk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R5C | down-regulates
binding
|
RPS6KB1 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20444422 |
The human homolog of pp2a-b', ppp2r5c, also counteracts s6k1 phosphorylation, indicating a conserved mechanism in mammals |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R5C | down-regulates
binding
|
Gbeta |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269900 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16456541 |
B56-containing pp2a dephosphorylate erk and their activity is controlled by the early gene iex-1 and erk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHEK2 | up-regulates
phosphorylation
|
PPP2R5C |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129255 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15380617 |
Found that chk2 associated with the b' regulatory subunit of protein phosphatase pp2a. In vitro kinase assays showed that b'gamma3 was a potent chk2 substrate. This phosphorylation increased the catalytic phosphatase activity of pp2a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IER3 | down-regulates
binding
|
PPP2R5C |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144309 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16456541 |
Iex-1 binds to b56 subunits and perk independently, enhances b56 phosphorylation by erk at a conserved ser/pro site in this complex and triggers dissociation from the catalytic subunit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R5C | down-regulates
binding
|
MAPK1 |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144325 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16456541 |
B56-containing pp2a dephosphorylate erk and their activity is controlled by the early gene iex-1 and erk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
PPP2R5C
- 
- 